PMID: 9169957Jun 1, 1997Paper

Channeling of three newly introduced antidepressants to patients not responding satisfactorily to previous treatment

Journal of Clinical Psychopharmacology
A C EgbertsH G Leufkens

Abstract

The demand for knowledge about differences in effectiveness, tolerability, safety, and economic outcomes between and within groups of antidepressant drugs when used in routine daily clinical practice is growing. For gaining this knowledge, observational pharmacoepidemiologic studies are often the most feasible option. However, the results of such studies can only be valid if either patient baseline characteristics associated with the outcome under study are similar or if differences can be adjusted for in the analysis. The aim of this study was to evaluate to what extent and for what type of patients three antidepressant drugs recently introduced in The Netherlands (mirtazapine, sertraline, and venlafaxine) were prescribed during the first year after their introduction and whether there were differences compared with longer-available antidepressant drugs. For this purpose, prescription drugs histories from 20 pharmacies serving a population of approximately 200,000 persons were analyzed. One year after their introduction, the newly introduced antidepressant t drugs accounted for approximately 6% of new uses of all antidepressant drugs. In comparison to longer-available antidepressant, the newly introduced antidepressant drugs w...Continue Reading

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Citations

Dec 25, 2004·European Journal of Clinical Pharmacology·P D KnoesterY A Hekster
Oct 18, 2005·Pharmacy World & Science : PWS·I SchillevoortH G M Leufkens
Mar 22, 2001·British Journal of Clinical Pharmacology·W E MeijerH G Leufkens
Mar 15, 2003·BMJ : British Medical Journal·Eibert R HeerdinkAntoine C G Egberts
Jul 16, 2008·European Journal of Clinical Pharmacology·Maurits E L ArbouwToine C G Egberts
Jun 8, 2002·Pharmacoepidemiology and Drug Safety·Deborah L AckermanMichael Gitlin
Aug 16, 2011·Forensic Science International : Synergy·Maria KingbäckFredrik C Kugelberg
Jul 16, 2010·Pharmacoepidemiology and Drug Safety·Hyungjin Myra KimMarcia Valenstein
Feb 9, 2006·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·E R BerndtA N Grudzinski
Sep 2, 2006·Journal of Psychopharmacology·David Taylor, J Railton Scott
Jan 7, 2003·Pharmacoepidemiology and Drug Safety·Welmoed E E MeijerHubert G M Leufkens
May 11, 2005·Pharmacoepidemiology and Drug Safety·Daniel MinesLaura Novelli
Jun 1, 2005·Pharmacoepidemiology and Drug Safety·Toine C G Egberts
Dec 19, 2019·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Johan ReutforsLena Brandt
Oct 28, 2004·Pharmacoepidemiology and Drug Safety·Nancy S Breekveldt-PostmaRon M C Herings
Jun 22, 2000·The Annals of Pharmacotherapy·K L MovigH G Leufkens

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