Chaperone Hsp47 Drives Malignant Growth and Invasion by Modulating an ECM Gene Network.

Cancer Research
Jieqing ZhuRen Xu

Abstract

The extracellular matrix (ECM) is a determining factor in the tumor microenvironment that restrains or promotes malignant growth. In this report, we show how the molecular chaperone protein Hsp47 functions as a nodal hub in regulating an ECM gene transcription network. A transcription network analysis showed that Hsp47 expression was activated during breast cancer development and progression. Hsp47 silencing reprogrammed human breast cancer cells to form growth-arrested and/or noninvasive structures in 3D cultures, and to limit tumor growth in xenograft assays by reducing deposition of collagen and fibronectin. Coexpression network analysis also showed that levels of microRNA(miR)-29b and -29c were inversely correlated with expression of Hsp47 and ECM network genes in human breast cancer tissues. We found that miR-29 repressed expression of Hsp47 along with multiple ECM network genes. Ectopic expression of miR-29b suppressed malignant phenotypes of breast cancer cells in 3D culture. Clinically, increased expression of Hsp47 and reduced levels of miR-29b and -29c were associated with poor survival outcomes in breast cancer patients. Our results show that Hsp47 is regulated by miR-29 during breast cancer development and progressi...Continue Reading

References

Oct 6, 1998·Annual Review of Biochemistry·J Massagué
Feb 2, 2002·Nature·Laura J van 't VeerStephen H Friend
Jul 13, 2002·The Journal of Biological Chemistry·Mohammed TasabNeil J Bulleid
Aug 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·Xin HuangTony E Godfrey
Dec 20, 2002·The New England Journal of Medicine·Marc J van de VijverRené Bernards
Dec 6, 2003·Journal of Cell Science·Dusko IlićCaroline H Damsky
Mar 31, 2006·Nature Reviews. Cancer·Raghu Kalluri, Michael Zeisberg
Jul 11, 2006·Annual Review of Cell and Developmental Biology·Celeste M Nelson, Mina J Bissell
Oct 27, 2006·Molecular Biology of the Cell·Atsuko YonedaJohn R Couchman
Dec 16, 2006·Trends in Molecular Medicine·Takashi Taguchi, M Shawkat Razzaque
Mar 31, 2007·Nature Methods·Genee Y LeeMina J Bissell
Apr 30, 2008·BMC Medicine·Paolo P ProvenzanoPatricia J Keely
May 3, 2008·Cancer Research·Courtney M WilliamsJean E Schwarzbauer
Sep 4, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jozien HellemanEls M J J Berns
Nov 29, 2008·Experimental Cell Research·Voon H OngChristopher P Denton
Dec 4, 2008·Cell Research·David Padua, Joan Massagué
Jan 13, 2009·Nature·David A QuigleyAllan Balmain
Jan 30, 2009·Molecular & Cellular Proteomics : MCP·Gereon PoschmannKai Stühler
Jul 29, 2009·Nature Reviews. Genetics·David Quigley, Allan Balmain
Nov 26, 2009·Cell·Kandice R LeventalValerie M Weaver
Apr 28, 2010·The AAPS Journal·Mengfeng LiShi-Yuan Cheng
Aug 10, 2010·Annual Review of Cell and Developmental Biology·Purva SinghJean E Schwarzbauer
Oct 5, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Christoph RoderburgTom Luedde
Oct 29, 2010·Cold Spring Harbor Perspectives in Biology·Pepper Schedin, Patricia J Keely
Dec 18, 2010·Integrative Biology : Quantitative Biosciences From Nano to Macro·Ren Xu, Jian-Hua Mao
Mar 3, 2011·PloS One·Espen EnerlyAnne-Lise Børresen-Dale
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Jun 28, 2011·Nature Medicine·Thordur OskarssonJoan Massagué
Dec 14, 2011·Molecular & Cellular Proteomics : MCP·Alexandra NabaRichard O Hynes
Jan 25, 2012·The Journal of Clinical Investigation·Lars MaegdefesselPhilip S Tsao
Feb 22, 2012·Cancer Research·Gaofeng XiongRen Xu
Feb 22, 2012·The Journal of Cell Biology·Pengfei LuZena Werb
Dec 4, 2012·Matrix Biology : Journal of the International Society for Matrix Biology·Alexandra NabaRichard O Hynes
Dec 25, 2012·Matrix Biology : Journal of the International Society for Matrix Biology·Colleen S Curran, Patricia J Keely
Mar 30, 2013·Cancer Research·Daniele M GilkesGregg L Semenza
Mar 7, 2014·Journal of Neuro-oncology·Dan ZhaoYongsheng Wang

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Citations

Jan 29, 2016·Biochemical and Biophysical Research Communications·Isao KiiAkira Kudo
Sep 21, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Fu PengJianping Chen
Nov 14, 2016·Seminars in Cell & Developmental Biology·Shinya Ito, Kazuhiro Nagata
Jan 8, 2017·Clinical and Experimental Pharmacology & Physiology·Yan QiFeng Li
Aug 29, 2018·International Journal of Urology : Official Journal of the Japanese Urological Association·Yasutaka YamadaNaohiko Seki
Sep 6, 2017·Scientific Reports·Abhishek KumarChandan Goswami
Aug 11, 2018·Molecular & Cellular Proteomics : MCP·Johnathon LiDietmar Kültz
Sep 14, 2019·International Journal of Molecular Sciences·Benjamin J LangStuart K Calderwood
Sep 16, 2019·Journal of Translational Medicine·Shuaishuai XuLiang Liu
Aug 22, 2018·Journal of Cancer Research and Clinical Oncology·Beatriz Dal Pont Duarte, Diego Bonatto
Aug 28, 2020·Frontiers in Oncology·Zahra Eslami-SCatherine Alix-Panabières
Jul 14, 2018·Frontiers in Cell and Developmental Biology·Yifei Qi, Ren Xu
Feb 6, 2020·Proceedings of the National Academy of Sciences of the United States of America·Gaofeng XiongRen Xu
Apr 2, 2020·BMC Molecular and Cell Biology·Essak S KhanAránzazu Del Campo
Nov 15, 2019·BMC Medical Genomics·Dongfang WangJin Gu
Mar 20, 2020·Molecular Cancer·Francesca CrudeleStefano Volinia
Dec 9, 2020·Expert Opinion on Therapeutic Targets·Pierre-Simon BellayeMartin Kolb
Aug 28, 2020·Pharmacology & Therapeutics·Ren XuChristine Trinkle
Jan 24, 2021·Laboratory Investigation; a Journal of Technical Methods and Pathology·Ting GuoCongjian Xu
Nov 1, 2018·Molecular & Cellular Proteomics : MCP·Johnathon LiDietmar Kültz
Mar 16, 2021·Frontiers in Oncology·Mianjie LinHaibin Chen
May 18, 2021·Cellular Signalling·Wenlong MaSong Wu
Apr 8, 2021·Annual Review of Biochemistry·Shinya Ito, Kazuhiro Nagata

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