Chaperones in hepatitis C virus infection

World Journal of Hepatology
Ronik Khachatoorian, Samuel W French

Abstract

The hepatitis C virus (HCV) infects approximately 3% of the world population or more than 185 million people worldwide. Each year, an estimated 350000-500000 deaths occur worldwide due to HCV-associated diseases including cirrhosis and hepatocellular carcinoma. HCV is the most common indication for liver transplantation in patients with cirrhosis worldwide. HCV is an enveloped RNA virus classified in the genus Hepacivirus in the Flaviviridae family. The HCV viral life cycle in a cell can be divided into six phases: (1) binding and internalization; (2) cytoplasmic release and uncoating; (3) viral polyprotein translation and processing; (4) RNA genome replication; (5) encapsidation (packaging) and assembly; and (6) virus morphogenesis (maturation) and secretion. Many host factors are involved in the HCV life cycle. Chaperones are an important group of host cytoprotective molecules that coordinate numerous cellular processes including protein folding, multimeric protein assembly, protein trafficking, and protein degradation. All phases of the viral life cycle require chaperone activity and the interaction of viral proteins with chaperones. This review will present our current knowledge and understanding of the role of chaperones i...Continue Reading

References

Aug 1, 1994·Trends in Biochemical Sciences·R B FreedmanM F Tuite
Jan 1, 1997·Journal of Virology·V DeleersnyderJ Dubuisson
Sep 18, 1997·The Journal of General Virology·J P MichalakJ Dubuisson
Dec 11, 1999·Current Topics in Microbiology and Immunology·J Dubuisson
Apr 5, 2000·The Journal of Biological Chemistry·D CourilleauJ Mester
Oct 17, 2001·Journal of Virology·M MerolaS Abrignani
Nov 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·L WaxmanP L Darke
Jan 31, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Gabriel PerlemuterChristian Bréchot
Mar 9, 2002·The Journal of Biological Chemistry·Agoritsa VarakliotiPenelope Mavromara
May 17, 2002·Critical Reviews in Clinical Laboratory Sciences·John R Burnett, P Hugh R Barrett
Sep 19, 2002·Biochemical and Biophysical Research Communications·Yoon Ki Kim, Sung Key Jang
Dec 28, 2002·Journal of Virology·Laurence CocquerelShoshana Levy
Jun 26, 2003·Journal of Gastroenterology·Kazuaki InoueMakoto Yoshiba
Oct 28, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Koichi WatashiKunitada Shimotohno
Dec 16, 2003·Biochemical and Biophysical Research Communications·Mina NakagawaMamoru Watanabe
Feb 13, 2004·The Journal of Biological Chemistry·Keith D TardifAleem Siddiqui
May 4, 2004·Biochemical and Biophysical Research Communications·Yook-Wah ChoiPhuay-Yee Goh
Sep 15, 2004·The Journal of Biological Chemistry·Seong-Jun KimJong-Won Oh
Oct 28, 2004·Gastroenterology·Hashem B El-Serag
Dec 18, 2004·Human Immunology·Yasunobu FukudaTomohiro Kato
Feb 26, 2005·Seminars in Liver Disease·Patrice AndréVincent Lotteau
Mar 17, 2005·Archives of Virology·A R CiccaglioneM Rapicetta
Apr 14, 2005·Journal of Biochemistry and Molecular Biology·Yi ZhengZhen-hui Wu

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Citations

Dec 7, 2017·Frontiers in Cell and Developmental Biology·Andrea MolinasElena Vikström
Nov 29, 2017·PloS One·Ana Claudia Silva BragaPaula Rahal
Jul 7, 2017·Journal of Caring Sciences·Yousef Haghighi MoghadamAram Feizi
Sep 15, 2020·Seminars in Cell & Developmental Biology·Kate DickerAlfredo Castello
Aug 23, 2019·Clinica Chimica Acta; International Journal of Clinical Chemistry·Azam Bolhassani, Elnaz Agi

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