Characterisation and expression of Sox9 in the Leopard gecko, Eublepharis macularius

The Journal of Experimental Zoology
E M ValleleyP L Coletta

Abstract

Since the discovery of the sex-determining gene, Sry, a number of genes have been identified which are involved in sex determination and gonadogenesis in mammals. Although Sry is known to be the testis-determining factor in mammals, this is not the case in non-mammalian vertebrates. Sox9 is another gene that has been shown to have a male-specific role in sex determination, but, unlike Sry, Sox9 has been shown to be involved in sex determination in mammals, birds, and reptiles. This is the first gene to be described that has a conserved role in sex determination in species with either chromosomal or environmental sex-determining mechanisms. Many reptiles do not have sex chromosomes but exhibit temperature-dependent sex determination (TSD). Sox9 has been shown to be expressed in both turtle and alligator during gonadogenesis. To determine if Sox9 also has a role in a gecko species with TSD, we studied gonadal expression of Sox9 during embryonic development of the Leopard gecko (Eublepharis macularius). Gecko Sox9 was found to be highly conserved at the nucleotide level when compared to other vertebrate species including human, chick, alligator, and turtle. Sox9 was found to be expressed in embryos incubated at the male-producing ...Continue Reading

References

Feb 1, 1992·Journal of Medical Genetics·A S Goldman, M A Hultén
May 9, 1991·Nature·P KoopmanR Lovell-Badge
Feb 11, 1993·Nucleic Acids Research·E M WrightP Koopman
May 1, 1993·The Journal of Experimental Zoology·B E VietsD Crews
May 25, 1993·Nucleic Acids Research·V LaudetH Clevers
Jul 15, 1998·The Journal of Experimental Zoology·L D SpotilaS E Hall
Mar 25, 1999·Developmental Dynamics : an Official Publication of the American Association of Anatomists·P S WesternA H Sinclair
Aug 14, 1999·The Journal of Biological Chemistry·S McDowallV Harley
Feb 24, 2000·Nucleic Acids Research·G E SchepersP Koopman

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Citations

Jul 10, 2003·General and Comparative Endocrinology·P K Elf
Feb 11, 2010·Sexual Development : Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation·T Rhen, A Schroeder
Mar 18, 2010·Sexual Development : Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation·T Gamble
Mar 21, 2017·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Maria Michela PallottaTeresa Capriglione
Sep 15, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Shuji TakadaPeter Koopman
Oct 31, 2012·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Nicole ValenzuelaRobert Literman
Dec 21, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Tohru KobayashiYoshitaka Nagahama
Aug 1, 2009·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Patrick A D WiseAnthony P Russell
Feb 28, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Christina ShoemakerDavid Crews
Apr 5, 2011·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Hélène DumondSandra Kuntz
Nov 22, 2008·Seminars in Cell & Developmental Biology·Christina M Shoemaker, David Crews

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