Characterisation and functional implications of the two new HLA-G alleles found in Amerindian and Caribbean populations

Human Immunology
A Arnaiz-VillenaEster Muñiz

Abstract

HLA-G polymorphism has been found to be relatively low in all world populations. In the present paper two new HLA-G molecules are described in ancient American natives. A new HLA-G molecule from a Ecuador Amerindian individual (male) showed four codon changes with respect to HLA-G*01:01:01. Silent changes at α1 domain (residue 57, Pro, CCG→CCA) and α2 domain (residue 93, His, CAC→CAT and residue 100, Gly, GGC→GGT) and one productive change in α3 domain (residue 219 changed from Arg to Trp). This α3 change may dramatically alter HLA-G interactions with beta-2 microglobulin, CD8, ILT-2 and ILT-4 ligands present in subsets of T, B, NK, monocytes, macrophages and dentritic cells. Another HLA-G new molecule was found in a woman from Hispaniola Island, Dominican Republic (Sto Domingo): it presented a silent change at α2 domain residue 107, Gly, GGA→GGT and non-silent change at residue 178, Met→Thr (with respect to HLA-G*01:01:01) which is close to class I molecule/clonotypic T cell receptor interaction sites. Functional implications of these findings are discussed.

References

Feb 11, 1999·American Journal of Human Genetics·F R SantosR J Mitchell
Mar 3, 1999·American Journal of Human Genetics·T M KarafetM F Hammer
Nov 7, 1999·Tissue Antigens·J Bruges-ArmasA Arnaiz-Villena
Nov 25, 2006·Molecular Immunology·Roberto AlegreAntonio Arnaiz-Villena
Jul 6, 2007·Tissue Antigens·J MoscosoA Arnaiz-Villena
Aug 9, 1996·Science·P Parham
Oct 7, 2010·Immunological Investigations·Carlos SilveraAntonio Arnaiz-Villena
Nov 26, 2010·Cellular and Molecular Life Sciences : CMLS·Eduardo A DonadiPhilippe Moreau
Nov 1, 2011·International Journal of Immunogenetics·Y ParkH-S Kim
Aug 22, 2014·Journal of Immunology Research·Vera RebmannPeter A Horn
Nov 22, 2014·Nucleic Acids Research·James RobinsonSteven G E Marsh

❮ Previous
Next ❯

Citations

May 16, 2017·International Journal of Immunogenetics·S G E Marsh
Jun 10, 2017·HLA : Immune Response Genetics·S G E Marsh, UNKNOWN by the WHO Nomenclature Committee for Factors of the HLA System

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Department of State Publication. Background Notes Series
United States. Department of State. Bureau of Public Affairs
International Journal of Stroke : Official Journal of the International Stroke Society
Conrado J Estol
Ohio Medicine : Journal of the Ohio State Medical Association
J G Ravin
Journal of Immunological Methods
D S AllanAndrew J McMichael
Seminars in Cancer Biology
Valeska Hofmeister, Elisabeth H Weiss
© 2022 Meta ULC. All rights reserved