Characterisation and functionality of inhalation anhydrous lactose

International Journal of Pharmaceutics
Chonladda PitchayajittipongStephen Edge

Abstract

The relationships between the physicochemical properties and functionality in dry powder inhaler (DPI) performance was investigated for inhalation grade anhydrous lactose and compared to monohydrate grades. The excipients were characterised using a range of techniques including particle size analysis, moisture sorption and powder rheometry. The inhalation anhydrous lactose grades were readily characterisable. The aerosolisation performance of capsule based DPI formulations containing budesonide (200microg) and different grades of lactose evaluated using inertial impaction measurements produced fine particle doses of budesonide ranging from 24 to 49microg. There were no apparent relationships between aerosolisation performance and excipient characteristics, such as particle size and powder density. However, formulations containing lactose grades which exhibit higher powder fluidisation energy values resulted in higher fine particle doses of budesonide.

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Citations

Nov 19, 2011·Journal of Pharmaceutical Sciences·Martin J DonovanHugh D Smyth
Nov 30, 2011·Advanced Drug Delivery Reviews·Xiang KouPaul W S Heng
Nov 29, 2011·Advanced Drug Delivery Reviews·Jagdeep Shur, Robert Price
May 28, 2011·Advanced Drug Delivery Reviews·Gabrielle PilcerKarim Amighi
Aug 16, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Ahmed O ShalashMustafa M A Elsayed
Sep 10, 2014·International Journal of Pharmaceutics·Sally SimDavid A V Morton
Jun 12, 2012·International Journal of Pharmaceutics·J P WillettsR H Bridson
Aug 23, 2017·Expert Opinion on Drug Delivery·Andrea Della BellaRuggero Bettini
Feb 13, 2020·Current Pharmaceutical Design·Rafael Guille SeoaneDamián Cordoba-Diaz

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