Characterisation of a novel poly (ether ether ketone)/calcium sulphate composite for bone augmentation

Biomaterials Research
Erik A B Hughes, Liam M Grover

Abstract

Calcium sulphate (CS) has been used in bone grafting since the 1800s. It has not replaced autograft as the gold standard, however, since its dissolution occurs rapidly in bodily fluids, meaning that the material cannot support long-term bone growth. Here, the polymer poly (ether ether ketone) (PEEK) was used to slow dissolution in in vitro physiological environments and augment the mechanical properties of the material. PEEK/CS specimens were fabricated by combining powders of PEEK and CS with water, resulting in a hardening paste. To enhance physical interactions between phases, cylindrical specimens were heat-treated to melt and fuse the PEEK. Following analysis of physical and chemical interactions by SEM and FT-IR respectively, dynamic ageing in PBS and compression testing was undertaken to measure how the PEEK influenced the mechanical properties of the final parts. Changes in structure and chemistry were determined using helium pycnometry, SEM and analysis of powder XRD patterns. Powders of PEEK and CS hemihydrate (CSH) (CaSO4.0.5H2O) were combined with PEEK at 0 wt%, 2.5 wt%, 20 wt%, 40 wt% and 80 wt% and at a P:L ratio of 0.85 g/mL. The subsequently hardened structures were heat-treated, which initiated the melting of P...Continue Reading

References

May 8, 1998·Biochemical and Biophysical Research Communications·T KamedaM Kumegawa
Jul 13, 2002·Journal of Biomedical Materials Research·M NilssonJ A Planell
Aug 9, 2002·The Journal of Arthroplasty·William MacaulayEduardo A Salvati
Oct 11, 2003·Clinical Implant Dentistry and Related Research·Elisabeth LiljenstenPeter Thomsen
Jan 23, 2004·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Giovanna OrsiniAdriano Piattelli
Nov 13, 2004·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Karin A Hing
May 13, 2006·Journal of Materials Science. Materials in Medicine·K N LewisD A Puleo
Jul 17, 2007·The Spine Journal : Official Journal of the North American Spine Society·Karin A HingThomas Buckland
Aug 10, 2007·Biomaterials·Steven M Kurtz, John N Devine
Mar 18, 2009·The Journal of Oral Implantology·Leonidas PodaropoulosDemos Kalyvas
Sep 2, 2009·Journal of Orthopaedic Surgery·Hamid Shegarfi, Olav Reikeras
Oct 14, 2009·Journal of Materials Science. Materials in Medicine·Gangfeng HuPeijian Tong
Nov 21, 2012·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Wenjuan LiuJiang Chang
Aug 16, 2013·Journal of Pharmacy & Bioallied Sciences·Prasanna KumarGhousia Fathima
Mar 8, 2014·Journal of the Mechanical Behavior of Biomedical Materials·Ilsoo KohStephen J Ferguson
Dec 3, 2016·Indian Journal of Orthopaedics·Manish Ramesh ShahShailendra H Gupta

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