Characterisation of acute ischemic stroke in patients with left ventricular thrombi after myocardial infarction

Journal of Thrombosis and Thrombolysis
Aloysius Sheng-Ting LeowLeonard Leong-Litt Yeo

Abstract

Acute ischemic stroke (AIS) is a feared complication in post-acute myocardial infarction (AMI) patients who develop left ventricular (LV) thrombus. There is limited data available on the incidence of stroke in this population, and characterisation of stroke subtypes has not been previously reported. Our study aims to evaluate the incidence of AIS in post-AMI patients with LV thrombus and to characterise the pattern of stroke subtypes. We screened 5829 patients with echocardiogram reports containing the "thrombus" keyword from August 2006 to September 2017. AIS that occurred after LV thrombosis was captured and relevant clinical data was collected. We identified 289 post-AMI patients with acute LV thrombus formation. Mean age was 59.3 ± 13.4 years. AIS occurred in 34 patients (11.8%), median duration of 20.5 days (IQR = 5.5-671.8) after LV thrombosis. Despite initial thrombus resolution, nine (5.2%) encountered AIS subsequently. Cardioembolic stroke subtype was identified in 76.5% of AIS, whilst 14.7% was small vessel disease and 8.8% was of large artery atherosclerosis subtype. Presence of thrombus protrusion (HR 3.04, 95% CI 1.25-7.41, p = 0.01), failure of initial thrombus resolution (HR 3.03, 95% CI 1.23-7.45, p = 0.02) and ...Continue Reading

References

May 1, 1988·Stroke; a Journal of Cerebral Circulation·J C van SwietenJ van Gijn
Sep 17, 2004·Clinical Pharmacology and Therapeutics·Feng ZhaoSoo Chin Lee
Jul 28, 2007·Stroke; a Journal of Cerebral Circulation·Deidre A De SilvaMeng-Cheong Wong
Mar 7, 2008·The New England Journal of Medicine·Ute I SchwarzC Michael Stein
Mar 18, 2008·The American Journal of the Medical Sciences·Marzenna ZielinskaMichał Tylkowski
Mar 29, 2008·Postgraduate Medical Journal·N U Weir
Apr 18, 2014·Journal of Stroke·Bum Joon Kim, Jong S Kim
May 7, 2016·Cardiology Clinics·Marius HornungHorst Sievert
Apr 1, 2017·Singapore Medical Journal·E Shyong TaiRob M van Dam
Apr 12, 2017·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Shafik KhouryYacov Shacham
Jun 8, 2017·Therapeutic Advances in Cardiovascular Disease·Fuad Habash, Srikanth Vallurupalli

❮ Previous
Next ❯

Citations

Feb 26, 2021·European Heart Journal. Case Reports·Alexander D HiltMarieke J H Wermer
Nov 6, 2021·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Yehia SalehNeal S Kleiman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

© 2022 Meta ULC. All rights reserved