Characterisation of advanced glycation endproducts in saliva from patients with diabetes mellitus

Biochemical and Biophysical Research Communications
Min-Sung YoonJoachim Jankowski

Abstract

Patients with diabetes mellitus are prone to develop increased advanced glycation endproducts causing local complications and increased overall morbidity and mortality. Nuclear magnetic resonance spectra were determined in saliva of 52 consecutive patients with diabetes mellitus and 47 age-matched healthy control subjects. Resonance spectra showed specific peaks at 2.3, 7.3, and 8.4 ppm in saliva from patients with diabetes mellitus. These peaks could be generated by incubation of saliva from healthy control subjects with hypochloric acid in vitro, indicating the presence of advanced glycation endproducts. The presence of advanced glycation endproducts in patients with diabetes mellitus was associated with approximal plaque index, indicating increased periodontal damage. The study indicates that increased advanced glycation endproducts are involved in the pathogenesis of diabetic complications.

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Citations

Nov 30, 2006·Analytical and Bioanalytical Chemistry·Michael S HodavanceIstván Pelczer
Aug 8, 2012·Lasers in Medical Science·Flavia Kazue IbukiFernando Neves Nogueira
Jul 16, 2010·Diabetology & Metabolic Syndrome·David A ScottKan-Zhi Liu
May 3, 2013·Journal of Clinical Periodontology·John J TaylorEvanthia Lalla
Feb 22, 2005·Biochemical and Biophysical Research Communications·Martin Grootveld, Christopher J L Silwood
Jul 10, 2009·Journal of Dental Research·P BullonM Battino
Apr 10, 2019·Frontiers in Endocrinology·Martijn J L VerhulstWijnand J Teeuw
May 10, 2020·Periodontology 2000·David PolakLior Shapira
Jun 9, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Roberto CodellaLivio Luzi

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