PMID: 8588309May 1, 1995Paper

Characterisation of African isolates of rinderpest virus

Veterinary Microbiology
H M WamwayiThomas Barrett

Abstract

Isolates of rinderpest virus (RPV) recovered from outbreaks of the disease in Kenya and Southern Sudan between 1986 and 1993 were compared to each other and to earlier isolates from East and West Africa. The recent isolates were mildly pathogenic for susceptible cattle and thus resembled other mild strains of RPV recovered from cattle and wildlife in East Africa more than 30 years ago. Monoclonal antibody analysis using a panel of 12 anti-RPV haemagglutinin protein-specific antibodies (mAbs) revealed that individual isolates were distinguishable. However, the panel of mAbs could not be used to relate the isolates on the basis of their pathogenicity or geographic origin. Immunoprecipitation of the virus-induced proteins from infected Vero cells, followed by SDS-polyacrylamide gel electrophoresis, showed that the recent mild RPV isolates from eastern Africa were closely related to each other and to their contemporary isolates from Nigeria and Egypt, but they were distinct from another mild isolate recovered from the region three decades ago. Two distinct lineages of African RPV isolates were identified by sequencing a region of the genome around the proteolytic enzyme cleavage site of the fusion protein from the old and new isola...Continue Reading

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Citations

May 1, 1995·Veterinary Microbiology·A DialloM Barbron
May 1, 1995·Veterinary Microbiology·M M Rweyemamu, Y Cheneau
Sep 1, 1996·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·L Haas, T Barrett
Jul 1, 1997·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·L Haas
Jan 1, 2012·Uirusu·Fumio Seki, Makoto Takeda
May 1, 1997·The Veterinary Journal·J M Rodriguez
Nov 22, 2005·The Journal of General Virology·J HeaneyT Barrett
Jul 14, 2010·Expert Review of Vaccines·Arnab SenRaj Kumar Singh
Nov 13, 1998·Journal of Virology·S E GalbraithS L Cosby
Feb 1, 1997·Journal of Virology·M D Baron, T Barrett

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