Characterisation of carotid atheroma in symptomatic and asymptomatic patients using high resolution MRI

Journal of Neurology, Neurosurgery, and Psychiatry
Jean M U-King-ImJ H Gillard

Abstract

To prospectively evaluate differences in carotid plaque characteristics in symptomatic and asymptomatic patients using high resolution MRI. 20 symptomatic and 20 asymptomatic patients, with at least 50% carotid stenosis as determined by Doppler ultrasound, underwent preoperative in vivo multispectral MRI of the carotid arteries. Studies were analysed both qualitatively and quantitatively in a randomised manner by two experienced readers in consensus, blinded to clinical status, and plaques were classified according to the modified American Heart Association (AHA) criteria. After exclusion of poor quality images, 109 MRI sections in 18 symptomatic and 19 asymptomatic patients were available for analysis. There were no significant differences in mean luminal stenosis severity (72.9% vs 67.6%; p = 0.09) or plaque burden (median plaque areas 50 mm(2) vs 50 mm(2); p = 0.858) between the symptomatic and asymptomatic groups. However, symptomatic lesions had a higher incidence of ruptured fibrous caps (36.5% vs 8.7%; p = 0.004), haemorrhage or thrombus (46.5% vs 14.0%; p<0.001), large necrotic lipid cores (63.8% vs 28.0%; p = 0.002) and complicated type VI AHA lesions (61.5% vs 28.1%; p = 0.001) compared with asymptomatic lesions. The ...Continue Reading

Citations

Sep 21, 2013·The New England Journal of Medicine·James C Grotta
Dec 4, 2012·Stroke; a Journal of Cerebral Circulation·Jeffrey D BodleTanya N Turan
Oct 29, 2011·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Zhongzhao TengJonathan H Gillard
Feb 9, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Umar SadatJonathan H Gillard
Dec 24, 2013·Canadian Association of Radiologists Journal = Journal L'Association Canadienne Des Radiologistes·Cyrille NaimGilles Soulez
Jul 31, 2012·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Umar SadatJonathan H Gillard
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Mar 1, 2012·Annals of Neurology·Wei-Hai XuLi-Ying Cui
Aug 6, 2013·IEEE Transactions on Bio-medical Engineering· Zhongzhao TengJonathan H Gillard
Feb 4, 2014·Journal of Biomechanics·Zhongzhao TengJonathan H Gillard
May 19, 2009·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·A J PattersonJ H Gillard
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