PMID: 3320967Dec 23, 1987Paper

Characterisation of cDNA clones for hypoxanthine-guanine phosphoribosyltransferase from the human malarial parasite, Plasmodium falciparum: comparisons to the mammalian gene and protein

Nucleic Acids Research
A King, D W Melton

Abstract

The isolation of cDNA clones for hypoxanthine-guanine phosphoribosyltransferase (HPRT) from the human malarial parasite, Plasmodium falciparum, is described. Northern analysis indicates that P. falciparum HPRT mRNA is the same size as that coding for mammalian HPRT. The predicted amino acid sequence of the P. falciparum HPRT protein shows extensive homology to the mammalian enzyme. Homology between the two proteins occurs in distinct blocks and a putative catalytic binding domain in the centre of the protein is also conserved. Five out of the seven characterised mammalian HPRT missense mutations map to regions which are conserved in the P. falciparum protein.

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Citations

Aug 1, 1990·Molecular and Biochemical Parasitology·A Saul, D Battistutta
Jun 1, 1990·Molecular and Biochemical Parasitology·M Shahabuddin, J Scaife
Jul 1, 1991·Molecular and Biochemical Parasitology·E de VriesP C van der Vliet
May 1, 1991·Molecular and Biochemical Parasitology·K J Robson, M W Jennings
Aug 1, 1992·Molecular and Biochemical Parasitology·R Cappai, A F Cowman
Nov 1, 1992·Molecular and Biochemical Parasitology·D J BzikB A Fox
Jul 1, 1995·Molecular and Biochemical Parasitology·T E AllenB Ullman
Sep 1, 1997·Molecular and Biochemical Parasitology·V M Marshall, R L Coppel
Jan 1, 1989·Parasitology·A H Fairlamb
Feb 1, 1989·The Journal of Cell Biology·M Kozak
Jun 24, 2008·Eukaryotic Cell·Megan J DownieChoukri Ben Mamoun
Aug 1, 1988·Experimental Parasitology·J L Weber
Apr 5, 2000·The Journal of Biological Chemistry·E L WhiteD W Borhani
Dec 2, 1991·Biochimica Et Biophysica Acta·D L Beckman, R G Kranz

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