PMID: 6405799May 25, 1983Paper

Characterisation of collagen from normal and scoliotic human spinal ligament

Biochimica Et Biophysica Acta
G VennR M Mason

Abstract

Acid-soluble and pepsin-soluble collagens have been isolated from spinal ligaments of normal and scoliotic individuals. Polyacrylamide gel electrophoresis of native and cyanogen bromide-treated collagens, and amino acid analysis, showed that the ligament collagen is almost all of the Type I variety with only trace amounts of Type III present. There was no evidence for abnormal ratios of collagen alpha-chains, or underhydroxylation of proline and lysine in the scoliotic ligament. These results indicate that collagen biochemistry is normal with respect to type, post-translational modification and cross-linking in spinal ligaments of patients with idiopathic scoliosis. Elastin and proteoglycan were only minor components of the ligaments. The nature of the non-collagenous part of the ligament is unknown, although it contains some proteins with a hydrophobic nature.

References

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Citations

Sep 1, 1993·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·S RobertsS M Eisenstein
Jan 1, 1989·International Orthopaedics·L H YahiaC H Rivard

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