Characterisation of excitatory and inhibitory transmitter systems in prostate glands of rats, guinea pigs, rabbits and pigs

European Journal of Pharmacology
A T Najbar-KaszkielM J Rand

Abstract

Excitatory and inhibitory transmitter systems were investigated in strips of prostate glands from rats, guinea pigs, pigs and rabbits. In strips from all species, electrical field stimulation (1 ms pulses at 1-30 Hz for 10 s) produced frequency-dependent contractions which were abolished by tetrodotoxin (1 microM). In strips from rats, guinea pigs and rabbits, contractions were reduced by prazosin (1 microM), guanethidine (10 microM) and atropine (2 microM), indicating the presence of noradrenergic and cholinergic mechanisms. However, the smooth muscle in the pig prostate appears to have a non-(nor)adrenergic non-cholinergic (NANC) excitatory innervation for which the transmitter was not identified. When noradrenergic and cholinergic mechanisms were blocked by guanethidine and atropine, respectively, and tone was raised with noradrenaline or methoxamine, field stimulation produced relaxations only in strips of rabbit prostate, and these were greatly reduced by N(G)-nitro-L-arginine methyl ester (L-NAME, 100 microM), providing functional evidence for a nitrergic relaxant innervation. In accord with this, nitric oxide (NO) synthase activity was considerably higher in rabbit than in rat or pig prostates.

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Citations

Dec 28, 1999·European Journal of Pharmacology·J N PennefatherS Ventura
Aug 23, 2002·Pharmacology & Therapeutics·S VenturaFrederick Mitchelson
Aug 24, 1999·British Journal of Pharmacology·W A LauF J Mitchelson
Jul 6, 2000·British Journal of Pharmacology·W A LauF J Mitchelson
Jan 23, 1999·Journal of Autonomic Pharmacology·W A LauJ N Pennefather
Sep 22, 2005·Clinical and Experimental Pharmacology & Physiology·John M Haynes, Sabatino Ventura
Dec 28, 2007·European Urology·Lambertus P W WitteMartin C Michel
Dec 15, 2015·Autonomic Neuroscience : Basic & Clinical·Michelle LamHikaru Hashitani
Jul 21, 2009·Neurourology and Urodynamics·Alexander RoosenChristopher H Fry
Mar 18, 2011·British Journal of Pharmacology·S VenturaB Exintaris
Nov 15, 2017·Nature Reviews. Urology·Fabiola Z Mónica, Edson Antunes
Feb 24, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·D Dunn-WaltersJ Spencer

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