Characterisation of immune responses in pancreatic carcinoma patients after mutant p21 ras peptide vaccination

British Journal of Cancer
M K GjertsenG Gaudernack

Abstract

This is a study of immune responses generated by mutant ras peptide vaccination of patients with pancreatic adenocarcinoma. Responding T cells from one patient were cloned and two CD4+ T-lymphocyte clones (TLC) specific for the 12 Val peptide and restricted by HLA-DR6 or DQ2 were obtained. These class II molecules have not previously been found to bind or present mutant ras peptides to T cells. The DR6-restricted TLC showed marked cytotoxicity against autologous target cells pulsed with the 12 Val peptide. Target cells pulsed with the control peptide were not killed. Responding T cells from another patient showed cross-reactivity towards the homologous ras peptides. Investigation by limiting dilution analysis (LDA) revealed different T-cell precursor frequencies for the immunising, mutant ras peptide (1:28000), compared with the normal ras peptide (1:110000).

Citations

Aug 15, 1998·Vox Sanguinis·M K Gjertsen, G Gaudernack
Mar 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·C N BaxevanisM Papamichail
Nov 1, 2001·Proceedings of the National Academy of Sciences of the United States of America·I SaeterdalG Gaudernack
May 26, 2005·Current Gastroenterology Reports·Christopher M HalloranJohn P Neoptolemos
Dec 19, 2002·Surgical Oncology Clinics of North America·Jennifer F Tseng, Richard C Mulligan

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