PMID: 9534748Apr 16, 1998Paper

Characterisation of Neisseria gonorrhoeae in semen during urethral infection in men

Genitourinary Medicine
S F IsbeyM S Cohen

Abstract

To determine the number of Neisseria gonorrhoeae organisms in urine and semen in men with gonococcal urethritis, and to compare selected phenotypic characteristics of organisms harvested from the urethra and semen. Samples from two groups of subjects were examined. Patients with symptomatic urethritis receiving treatment at an STD clinic, as well as six subjects with experimental urethritis. Semen and urine specimens were obtained after the urethral exudate was sampled. Using quantitative cultures, we found an average of 6 x 10(6) gonococci in urine or semen of 17 men with symptomatic urethritis seeking treatment at an STD clinic, and 2 x 10(4) gonococci in secretions of six male subjects with early experimental infection. Gonococcal outer membrane opacity (Opa) proteins and lipo-oligosaccharide (LOS) recovered from urine and semen of these subjects were very similar. Men with symptomatic gonorrhoea excrete a large number of gonococci in semen which is not affected by the duration of symptoms. The similar phenotype of organisms in urine and semen suggests the bacteria come from the same compartment. These data help to explain the efficiency of gonococcal transmission from men to their partners, and identify an appropriate targe...Continue Reading

References

Aug 1, 1978·American Journal of Epidemiology·R R HooperK K Holmes
Jul 24, 1975·The New England Journal of Medicine·D A EschenbachK K Holmes
Jun 1, 1976·The Journal of Infectious Diseases·T L Lowe, S J Kraus
Jun 1, 1992·The Journal of Clinical Investigation·M S Cohen, P F Sparling
May 1, 1990·Microbial Pathogenesis·A A CampagnariM A Apicella
Jul 1, 1990·Reviews of Infectious Diseases·J S Moran, J M Zenilman
May 1, 1987·The Journal of Experimental Medicine·J SwansonJ M Koomey
Feb 1, 1970·American Journal of Epidemiology·K K HolmesH J Trostle
Jan 1, 1982·Analytical Biochemistry·C M Tsai, C E Frasch
Dec 1, 1980·American Journal of Obstetrics and Gynecology·K K HolmesJ S Knapp
Jul 1, 1995·The Journal of Infectious Diseases·H SchneiderC D Deal
Mar 1, 1994·The Journal of Experimental Medicine·A E JerseJ G Cannon
Feb 15, 1994·Annals of Internal Medicine·M S CohenK K Holmes
Jan 1, 1993·Vaccine·R F Bishop
Apr 10, 1997·The New England Journal of Medicine·R A RoyceM S Cohen

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Citations

Apr 16, 2008·Infection and Immunity·Rachel R Spurbeck, Cindy Grove Arvidson
Sep 17, 2005·Molecular Microbiology·Jean A Cardinale, Virginia L Clark
Jun 13, 2020·ACS Applied Materials & Interfaces·María Isabel LucíoAntonios G Kanaras

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