Characterisation of proton pump antibodies and stomach pathology in gastritis induced by neonatal immunisation without adjuvant

Autoimmunity
Deanne L V GreenwoodB H Toh

Abstract

It has previously been reported that neonatal BALB.D2 mice injected with native proton pump antigens without adjuvant develop an irreversible gastritis (Claeys et al, 1997). The ease of inititating gastritis in the neonate stands in contrast with the difficulty in initiating gastritis in adult mice that require repeated immunisation in adjuvant that is reversible following cessation of immunisation (Scarff et al, 1997). In view of these contrasting observations, we set out to ascertain whether we could confirm the observations in neonatal mice as well as further characterise the pathology and the autoantibody response. We found that neonatal gastritis-susceptible BALB/c mice (n=12), immunised with either pig or mouse gastric membranes in the absence of adjuvant, develop gastritis without circulating antibody to parietal cells detected by immunofluorescence, a hallmark of murine and human gastritis (Toh et al, 1997). However, mice immunized with pig gastric membranes (n=6) had circulating antibodies reactive by immunofluorescence to recombinant alpha and/or beta subunit of gastric H+/K+-ATPase expressed by insect cells (Sfalpha and Sfbeta). Four mice from this cohort with antibodies to Sfbeta also had reactivity to gastric H+/K+...Continue Reading

References

Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·B H TohD C Humphris
Jan 1, 1981·Immunogenetics·A Kojima, R T Prehn
Jan 1, 1995·European Journal of Immunology·S P BarrettP A Gleeson
Feb 1, 1996·Immunological Reviews·P A GleesonI R van Driel
Nov 14, 1997·The New England Journal of Medicine·B H TohP A Gleeson
Jun 24, 1999·Immunology Today·B Adkins
Jan 19, 2000·Immunology Today·S Marshall-ClarkeJ Hassan

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Citations

Jan 25, 2008·European Journal of Pediatrics·Deanne L V GreenwoodJohn W Sentry
Oct 13, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Deanne L V Greenwood, John W Sentry
Jan 10, 2002·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Frank AlderuccioBan Hock Toh
Mar 15, 2005·International Reviews of Immunology·J FieldB-H Toh

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