PMID: 428696Apr 1, 1979Paper

Characterisation of somatostatin release from the pancreas: the role of calcium and acetylcholine

Diabetologia
K HermansenH Orskov

Abstract

The effect of calcium on somatostatin secretion was investigated in the isolated, perfused canine pancreas preparation and compared with those of acetylcholine, glucose, isoproterenol and arginine. Calcium (5 mmol/l) stimulated somatostatin release in a typical biphasic response pattern being about 5 times as potent as acetylcholine (1 mumol/l), arginine (5 mmol/l), and isoproterenol (2 ng/ml) while the release of insulin and glucagon in response to calcium and the other secretagogues were of the same magnitude. Somatostatin release increased progressively when perfusate calcium was increased step-wise from 0 through 1.25 and 2.5 to 5.0 mmol/l. Calcium stimulated the secretion of somatostatin in the absence of glucose. The stimulatory effect of calcium was, however, modulated by the glucose concentration being about twice as large at 200 mg/100 ml as at 25 mg/100 ml glucose in the perfusion medium.

References

Jan 14, 1978·Diabetologia·R LuftT Hökfelt
Apr 1, 1977·Scandinavian Journal of Clinical and Laboratory Investigation·K Hermansen, J Iversen
Jul 15, 1978·Clinica Chimica Acta; International Journal of Clinical Chemistry·V HarrisR H Unger
Dec 15, 1976·Life Sciences·G S PattonR H Unger
Aug 1, 1977·Diabetologia·J Iversen, K Hermansen
Mar 1, 1975·Proceedings of the Society for Experimental Biology and Medicine·A ArimuraA V Schally
Dec 8, 1973·Lancet·K G AlbertiH Orskov
Dec 1, 1973·Scandinavian Journal of Clinical and Laboratory Investigation·J Weeke, H Orskov
Apr 1, 1974·Scandinavian Journal of Clinical and Laboratory Investigation·J Iversen
Jun 1, 1974·European Journal of Clinical Investigation·H Orskov, K Seyer-Hansen

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Citations

Mar 1, 1981·Diabetologia·E SamolsG C Weir
Jul 1, 1980·Diabetologia·K Hermansen
Dec 1, 1980·Molecular and Cellular Endocrinology·P SchauderW Creutzfeldt
Dec 1, 1979·Scandinavian Journal of Clinical and Laboratory Investigation·K HermansenH Orskov
Mar 1, 1981·The American Journal of Medicine·J E Gerich
Apr 1, 1989·Diabetes Research and Clinical Practice·H YasudaH Oka
Jan 1, 1986·Scandinavian Journal of Gastroenterology. Supplement·V Schusdziarra, R Schmid
Mar 1, 1981·Diabetologia·E SamolsG C Weir
Feb 11, 1986·The American Journal of Physiology·B AhrénG J Taborsky
Nov 1, 1982·The American Journal of Physiology·P Ronner, A Scarpa
Aug 1, 1981·The American Journal of Physiology·S SeinoH Imura
Apr 1, 1984·The American Journal of Physiology·G PittengerL Wagner
Dec 1, 1983·The American Journal of Physiology·J J HolstO V Nielsen
Apr 1, 1981·The Journal of Surgical Research·K R SirinekS Cataland
Apr 1, 1997·Metabolism: Clinical and Experimental·A BertsB Hellman
Dec 1, 1995·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·F C BrunicardiD K Andersen
Oct 1, 1996·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·K HermansenB Ahrén

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