PMID: 8938857Nov 1, 1996Paper

Characterisation of the acute phase response of heifers to a prolonged low dose infusion of lipopolysaccharide

Research in Veterinary Science
D WerlingW Langhans

Abstract

The effect of a prolonged low dose infusion of bacterial lipopolysaccharide (LPS) on acute phase-like reactions was examined in heifers. LPS (2 micrograms kg-1 dissolved in 100 ml water), or saline was infused (at 1 ml min-1) intravenously for 100 minutes and blood samples were taken at various times before, during and after the infusion. The serum concentrations of tumour necrosis factor-alpha (TNF alpha), interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6) and serum amyloid A (SAA) and the rectal temperature increased in response to the LPS infusion. Serum TNF alpha increased before the increases in IL-1 beta and IL-6 and remained high from 20 minutes after the onset of the infusion until the end of the sampling period (six hours). The LPS-induced increases in serum IL-1 beta and IL-6 were biphasic. Plasma cortisol and lactate concentrations also increased, and plasma glucose and beta-hydroxybutyrate concentrations decreased in response to the LPS infusion. The similarity of these reactions to changes observed in response to bacterial infections shows that the prolonged infusion of low doses of LPS is a good model for studying the acute phase response to Gram-negative bacterial infection in heifers.

References

Jan 6, 1989·Journal of Immunological Methods·A MeagerJ Woolley
Dec 1, 1988·The Journal of Nutrition·K C Klasing
Mar 1, 1988·Gastroenterology·S J van DeventerG N Tytgat
Feb 1, 1994·Immunology Today·H Baumann, J Gauldie
Jan 1, 1995·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·M SennW Langhans
Feb 1, 1994·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·E T RietschelF Di Padova
Jan 1, 1994·Gut·P A Van LeeuwenR I Wesdorp
Jan 1, 1993·Veterinary Immunology and Immunopathology·L W PaceW H Fales
Nov 1, 1995·Veterinary Immunology and Immunopathology·Z J JianP N Bochsler
Sep 1, 1994·Zentralblatt für Veterinärmedizin. Reihe A·M KinsbergenJ W Blum

❮ Previous
Next ❯

Citations

Aug 25, 2004·Comparative Immunology, Microbiology and Infectious Diseases·T OrroT Soveri
May 26, 2004·The Veterinary Journal·H MurataM Yoshioka
Feb 1, 2011·Toxicological and Environmental Chemistry·Azam F TayabaliVerner L Seligy
Oct 28, 2005·Journal of Zhejiang University. Science. B·E GruysS J Koopmans
Aug 21, 2013·The Veterinary Record·L Seppä-LassilaT Soveri
Jan 16, 2016·Environmental Health : a Global Access Science Source·R John WallaceLubomir Leng
Apr 7, 2007·The Veterinary Journal·Toomas OrroTimo Soveri
Nov 15, 2006·Journal of Comparative Pathology·J C Hodgson
Aug 13, 2015·Comparative Immunology, Microbiology and Infectious Diseases·Leena Seppä-LassilaTimo Soveri
Jul 29, 2015·Veterinary Parasitology·Brian LassenToomas Orro
Dec 24, 2014·Veterinary Immunology and Immunopathology·Elke PlessersSiska Croubels
Jun 25, 2016·BMC Veterinary Research·Umit KarademirGamze Sevri Ekren Asici
Jan 22, 2005·Veterinary Immunology and Immunopathology·S JacobsenE Gruys
Mar 6, 2018·Journal of Animal Science·D M MeléndezK S Schwartzkopf-Genswein
Jun 26, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Noko R MphahlelePeter R Kamerman
Apr 9, 2009·Veterinary Clinical Pathology·Yannick RomanMichel Saint Jalme
Jul 8, 1998·Immunopharmacology and Immunotoxicology·A EstradaB Li
Nov 11, 2011·The Korean Journal of Parasitology·Mohammad HashemniaSaeed Nazifi
May 11, 2012·Journal of Animal Science·C A GiffordC R Krehbiel
Dec 23, 2008·Journal of Animal Science·B N AmetajK A Beauchemin
Jan 14, 2021·Animals : an Open Access Journal From MDPI·Jennifer MeyerSven Dänicke

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.