PMID: 7915050Jul 1, 1994Paper

Characterisation of the beta adrenergic response cascade in fetal guinea pig lung

Thorax
M E LyonD J Davis

Abstract

Suitable models for the study of lung development are needed. The suitability of the guinea pig for studying the role of the beta adrenergic response cascade in fetal lung development has been evaluated. Radioligand binding assays with iodine-125 labelled iodopindolol were performed to identify and characterise the beta adrenergic receptors. To demonstrate that these receptors were functional, isoprenaline and forskolin stimulated generation of cyclic AMP (cAMP) in the lung tissue was quantitated by radioimmunoassay. The concentration of beta receptors increased with gestational age from 23 fmol/mg at 35 days to 140 fmol/mg at 64 days. Competition binding studies were consistent with a predominance of beta 2 receptors. The ability of isoprenaline to stimulate cAMP generation was greater during the saccular phase than during the canalicular phase of lung development. Incorporation of tritium labelled choline into phosphatidylcholine increased significantly between the canalicular and saccular phases. The beta adrenergic response cascade in fetal guinea pig lung exhibits similar characteristics to those previously described in fetal human lung and is therefore a good model in which to study the effects of beta agonists on fetal l...Continue Reading

References

Mar 28, 1986·Biochemical and Biophysical Research Communications·G FalkayL Kovács
Mar 1, 1986·Ultrasound in Medicine & Biology·Z Kaneko
May 1, 1986·Journal of Applied Physiology·J V McDonaldJ M Roberts
Feb 13, 1987·Biochemical and Biophysical Research Communications·S K DasP Skolnick
Sep 1, 1986·Clinical Obstetrics and Gynecology·K C Pringle
Nov 1, 1986·The Anatomical Record·M H CollinsW A Blanc
Dec 1, 1984·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·C GattoD E Johnson
Mar 1, 1982·The American Journal of Anatomy·A J Lechner, N Banchero
Jul 15, 1981·Developmental Biology·J M SnyderJ M Johnston

❮ Previous
Next ❯

Citations

Nov 11, 2008·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Brian Wu, Dennis W Nielson
Oct 8, 2008·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Anne HilgendorffHermann Lindemann

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Related Papers

American Journal of Respiratory and Critical Care Medicine
Georg HülskampJanet Stocks
Lancet
Michael Silverman, Claudia E Kuehni
The European Respiratory Journal
M GappaERS/ATS Task Force on Standards for Infant Respiratory Function Testing. European Respiratory Society/American Thoracic Soci
Pediatric Pulmonology
Beverley RobinAmy Goldstein-Filbrun
© 2021 Meta ULC. All rights reserved