Characterisation of the discriminative stimulus properties of flumazenil

European Journal of Pharmacology
F Woudenberg, J L Slangen


Rats were trained to discriminate flumazenil (15 mg/kg i.p.) from vehicle in a two-lever, food-reinforced, operant conditioning procedure. Substitution tests were performed with a wide dose range of flumazenil and of several benzodiazepines and non-benzodiazepine compounds possessing behavioural effects similar to or opposite to those of benzodiazepine agonists. The results indicate that low doses of flumazenil have behavioural effects, that the flumazenil cue has a low degree of specificity and is most strongly related to the stimulus properties of benzodiazepines.


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Related Concepts

Operant Conditioning
Discrimination (Process of Differentiation)
Dose-Response Relationship, Drug
Extinction, Psychological
August Rats
Rats, Laboratory

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