Characterisation of the lymph node immune response following Mycoplasma mycoides subsp. Mycoides SC infection in cattle

Veterinary Research
Laurence DedieuMamadou Niang

Abstract

Contagious bovine pleuropneumonia (CBPP), caused by Mycoplasma mycoides subsp. mycoides biotype Small Colony (MmmSC), is still a major cattle disease in Africa. Development of long-term protective vaccines, the only relevant strategy to achieve CBPP eradication, requires the characterisation of the protective immune mechanism. To this aim, the present study investigated the cellular immune response persisting in the lymph nodes of cattle infected naturally and experimentally by contact, one year post exposure. The lymph node cell composition, MmmSC responsiveness and phenotype of the MmmSC-responding lymphocytes were compared between animals according to the different outcomes of the infection. To unravel the protective mechanism, the study focussed on the MmmSC-specific memory immune response generated in recovered cattle, known to develop long-term immunity and to be resistant to reinfection. An MmmSC-specific immune response, mediated by IFNgamma-secreting CD4 T-cells, was detected in the lymph nodes of all recovered cattle. Furthermore, the magnitude of this immune response was significantly higher in animals with complete recovery than in recovered animals presenting lung sequestra. The findings suggest that, in recovered ...Continue Reading

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Citations

Jun 11, 2010·Clinical and Vaccine Immunology : CVI·Philippe TottéLaurence Dedieu
May 12, 2020·Veterinary Pathology·Giovanni Di TeodoroMassimo Scacchia
Oct 23, 2015·Veterinary Research·Philippe TottéFrançois Thiaucourt
Feb 4, 2009·Comparative Immunology, Microbiology and Infectious Diseases·Laurence DedieuJoachim Frey

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