Characterising acute coronary syndrome-associated depression: Let the data speak

Brain, Behavior, and Immunity
Uté Vollmer-ConnaGordon Parker

Abstract

Depression in the context of acute coronary syndrome (ACS) is understood to confer increased morbidity and mortality risk. The pathophysiological mechanisms underlying this association remain poorly understood, although several candidates including inflammation, cardiac autonomic dysregulation, and behavioural factors are viewed as of key importance. No single bio-behavioural explanatory model of ACS-associated depression has emerged, likely due the substantial heterogeneity across both conditions. We studied 344 patients with ACS; 45 fulfilled diagnostic (DSM-IV) criteria for a major depressive episode occurring within 1-month of ACS, and 13 had ongoing major depression that pre-dated ACS and continued through to 1 month post-ACS. We employed two statistical methods (multinomial logistic regression; and latent class analysis) and a range of immunological, autonomic and nutritional markers in an attempt to characterise a biological basis for ACS-associated depression. Regression modelling failed to accurately predict categorical group membership of ACS-associated depression. An alternative data-driven approach produced a three-class solution, with the derived classes differing on measure of C-reactive protein, vitamin D, omega-...Continue Reading

References

Aug 30, 1984·The New England Journal of Medicine·W RubermanB S Chaudhary
Jan 1, 1993·Journal of Psychosomatic Research·S LevensteinA Andreoli
Mar 1, 1996·Journal of Clinical Epidemiology·M Von KorffG E Simon
Jun 13, 2002·Acta Psychiatrica Scandinavica·G ParkerD Hadzi-Pavlovic
Jan 18, 2003·Sleep Medicine Reviews·Joëlle Adrien
Jun 3, 2004·Nature Reviews. Immunology·Penelope A BryantNigel Curtis
Jul 13, 2005·Archives of Internal Medicine·Robert M CarneyAllan S Jaffe
Aug 17, 2005·Sleep Medicine Reviews·Mark R Opp
Dec 22, 2006·Biological Psychology·Julian F Thayer, Richard D Lane
May 15, 2007·Medical Hypotheses·Michael BerkSeetal Dodd
Nov 7, 2007·European Heart Journal·Wolfgang LindenJocelyne Leclerc
Jan 9, 2008·Circulation·Thomas J WangRamachandran S Vasan
Jul 8, 2008·Biological Psychiatry·Gordon B ParkerDusan Hadzi-Pavlovic
Dec 27, 2008·Progress in Cardiovascular Diseases·Janet M MullingtonHans K Meier-Ewert
Jan 20, 2009·Biological Psychiatry·Andrew H MillerCharles L Raison
Mar 31, 2009·Journal of the American Dietetic Association·Natalie D RiedigerMohammed H Moghadasian
May 1, 2009·Autonomic Neuroscience : Basic & Clinical·Kohzoh Yoshino, Katsunori Matsuoka
Jul 29, 2009·Brain, Behavior, and Immunity·Nancy Frasure-SmithBruce G Pollock
Aug 22, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Jorge N ArtazaKeith C Norris
Aug 28, 2009·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Heather N RasmussenJoel B Greenhouse
Feb 4, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A L HasselbalchT I A Sørensen
Feb 5, 2010·The American Journal of Clinical Nutrition·Katherine M AppletonAndrew R Ness
Apr 13, 2010·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Johannes M W van den OuwelandHenny van Daal
Apr 28, 2010·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·C Barr Taylor
Jun 24, 2010·American Heart Journal·Heidi T MayJoseph B Muhlestein
Aug 3, 2010·Brain, Behavior, and Immunity·Julian F Thayer, Esther M Sternberg
Aug 18, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·N J TimpsonG Davey Smith
Nov 3, 2010·Psychoneuroendocrinology·Robert DantzerKeith W Kelley
Feb 9, 2011·Journal of Affective Disorders·Chiara BaglioniDieter Riemann

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.