Characterising granuloma regression and liver recovery in a murine model of schistosomiasis japonica

International Journal for Parasitology
Candy ChuahGeoffrey N Gobert

Abstract

For hepatic schistosomiasis the egg-induced granulomatous response and the development of extensive fibrosis are the main pathologies. We used a Schistosoma japonicum-infected mouse model to characterise the multi-cellular pathways associated with the recovery from hepatic fibrosis following clearance of the infection with the anti-schistosomal drug, praziquantel. In the recovering liver splenomegaly, granuloma density and liver fibrosis were all reduced. Inflammatory cell infiltration into the liver was evident, and the numbers of neutrophils, eosinophils and macrophages were significantly decreased. Transcriptomic analysis revealed the up-regulation of fatty acid metabolism genes and the identification of Peroxisome proliferator activated receptor alpha as the upstream regulator of liver recovery. The aryl hydrocarbon receptor signalling pathway which regulates xenobiotic metabolism was also differentially up-regulated. These findings provide a better understanding of the mechanisms associated with the regression of hepatic schistosomiasis.

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Citations

Jul 25, 2017·Diseases of Aquatic Organisms·Jerko HrabarIvona Mladineo
Nov 8, 2018·Laboratory Investigation; a Journal of Technical Methods and Pathology·Marina C G HarvieGeoffrey N Gobert
Aug 4, 2020·Parasitology·Sujeevi S K NawaratnaGeoffrey N Gobert
Nov 22, 2017·Revista Da Sociedade Brasileira De Medicina Tropical·Renata Russo Frasca CandidoCarlos Graeff-Teixeira
Aug 8, 2020·Frontiers in Microbiology·Yuzheng HuangJun Cao
Dec 19, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hong YouDonald P McManus
Mar 6, 2021·Helminthologia·R A Gomes AssençoR Guerra-Sá

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