Characterising phospholipids and free fatty acids in patients with schizophrenia: A case-control study.

The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry
Dongfang WangBing Cao

Abstract

Previous studies have indicated that schizophrenia (SCZ) is linked to abnormal phospholipid and fatty acid metabolism. However, comprehensive analysis of phospholipids and free fatty acids (FFAs) for SCZ is very limited. Herein, we sought to compare serum levels of phospholipids and FFAs between patients with SCZ and healthy controls (HCs). One hundred and nineteen SCZ patients and 109 HCs were enrolled in the study. The levels of 177 phospholipids and FFAs were measured in serum samples using a targeted liquid chromatography-mass spectrometry (LC-MS)-based platform. One hundred and ten metabolites, including 16 FFAs, 25 phosphatidylcholines, 23 lysophosphatidylcholines, 11 phosphatidylcholine plasmalogens, 7 phosphatidylethanolamines, 9 lysophosphatidylethanolamines, 6 phosphatidylethanolamine plasmalogens, and 13 sphingomyelins, were observed to be significantly altered in SCZ patients compared to HCs. These disturbances may represent underlying pathophysiology, including but not limited to altered activity of phospholipases and acyltransferases, increased oxidative stress, dysfunctional oligodendrocyte glycosynapses, and elevated lipid mobilisation and β-oxidation. Our findings suggest that complex lipid profile abnormalitie...Continue Reading

References

Jan 1, 1985·Progress in Lipid Research·P S Sastry
Oct 1, 1993·Psychiatry Research·M S KeshavanC Dippold
Mar 31, 1999·Schizophrenia Bulletin·J Addington, D Addington
Nov 18, 2000·Biochimica Et Biophysica Acta·S Nigam, T Schewe
Oct 12, 2001·Schizophrenia Research·A M PonizovskyL D Bergelson
Aug 16, 2002·Molecular Biology of the Cell·Marian Groot KoerkampHenk F Tabak
May 14, 2003·Archives of General Psychiatry·Kenneth L DavisVahram Haroutunian
Nov 19, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·P D Skosnik, J K Yao
Mar 20, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Peter StenvinkelOlof Heimbürger
Jun 29, 2004·Biological Psychiatry·Andrea SchmittWagner F Gattaz
Jan 18, 2006·Disease Markers·Jeffrey K YaoRavinder Reddy
Feb 21, 2006·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Eva WarensjöBengt Vessby
Apr 19, 2007·Molecular Psychiatry·R Kaddurah-DaoukK R R Krishnan
May 16, 2008·Epidemiologic Reviews·John McGrathJoy Welham
Sep 5, 2008·Analytical Chemistry·Sankar MahadevanCarolyn M Slupsky
Sep 9, 2008·Cell·Elaine HolmesJeremy K Nicholson
Jul 3, 2009·Atherosclerosis·Gerd Schmitz, Katharina Ruebsaamen
Aug 13, 2010·Journal of Proteome Research·Marc Chadeau-HyamMaria De Iorio
Oct 26, 2011·Molecular Psychiatry·J YangC Wan
Nov 15, 2011·Biochemical and Biophysical Research Communications·Hitoshi HasegawaMasaki Yasukawa
Apr 4, 2012·Current Protocols in Molecular Biology·Lee D RobertsClary B Clish
Apr 20, 2012·Psychiatry Research·Rima Kaddurah-DaoukHenry A Nasrallah
Sep 11, 2012·Biochimica Et Biophysica Acta·Jean E Vance, Guergana Tasseva
Sep 18, 2012·Schizophrenia Research·W J M van der KempH E Hulshoff Pol
Nov 8, 2012·Future Oncology·Haiwei GuDaniel Raftery
Mar 29, 2014·Current Neuropharmacology·Samina Salim
May 26, 2015·Schizophrenia Research·Paul L Wood, Nicole R Holderman
Aug 21, 2015·Biochimica Et Biophysica Acta·Martin ReichelJohannes Kornhuber
Oct 11, 2015·The International Journal of Neuropsychopharmacology·Sumit Sethi, Elisa Brietzke
Nov 12, 2015·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Sumit SethiElisa Brietzke
Nov 24, 2016·Frontiers in Neuroscience·Rolando I CastilloPablo A Gaspar
Jan 31, 2017·Advances in Experimental Medicine and Biology·Sumit SethiElisa Brietzke

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