Characterising resting-state functional connectivity in a large sample of adults with ADHD

Progress in Neuro-psychopharmacology & Biological Psychiatry
Jeanette C MostertDavid G Norris

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is a common childhood psychiatric disorder that often persists into adulthood. While several studies have identified altered functional connectivity in brain networks during rest in children with ADHD, few studies have been performed on adults with ADHD. Existing studies have generally investigated small samples. We therefore investigated aberrant functional connectivity in a large sample of adult patients with childhood-onset ADHD, using a data-driven, whole-brain approach. Adults with a clinical ADHD diagnosis (N=99) and healthy, adult comparison subjects (N=113) underwent a 9-minute resting-state fMRI session in a 1.5T MRI scanner. After elaborate preprocessing including a thorough head-motion correction procedure, group independent component analysis (ICA) was applied from which we identified six networks of interest: cerebellum, executive control, left and right frontoparietal and two default-mode networks. Participant-level network maps were obtained using dual-regression and tested for differences between patients with ADHD and controls using permutation testing. Patients showed significantly stronger connectivity in the anterior cingulate gyrus of the executive control net...Continue Reading

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Citations

Feb 6, 2017·Neuroscience and Biobehavioral Reviews·Marieke KleinBarbara Franke
Sep 9, 2017·Brain Connectivity·Tanzil Mahmud ArefinLaura-Adela Harsan
Sep 28, 2018·Journal of Attention Disorders·Haixi LinXiaoqi Huang
Apr 25, 2019·The American Journal of Psychiatry·Martine HoogmanBarbara Franke
Nov 7, 2019·Brain Imaging and Behavior·Pradyumna LankaGopikrishna Deshpande
Jun 22, 2017·Cerebral Cortex·R A I BethlehemS Baron-Cohen
Mar 16, 2017·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Dienke J BosSarah Durston
Apr 11, 2019·Frontiers in Human Neuroscience·Elisabeth ColonDavid Borsook
Oct 20, 2020·Journal of Personality Disorders·Mohammad H AfzaliPatricia Conrod
Sep 19, 2020·Journal of the American Academy of Child and Adolescent Psychiatry·Samuele CorteseSimon B Eickhoff
Jun 7, 2021·Translational Psychiatry·Santosh K YadavMohammad Haris
Jul 22, 2021·Journal of Neural Engineering·Maliheh AhmadiArdalan Aarabi

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