Characterising the disintegration properties of tablets in opaque media using texture analysis

International Journal of Pharmaceutics
Rebekah L ScheuerleKrishnaa T Mahbubani

Abstract

Tablet disintegration characterisation is used in pharmaceutical research, development, and quality control. Standard methods used to characterise tablet disintegration are often dependent on visual observation in measurement of disintegration times. This presents a challenge for disintegration studies of tablets in opaque, physiologically relevant media that could be useful for tablet formulation optimisation. This study has explored an application of texture analysis disintegration testing, a non-visual, quantitative means of determining tablet disintegration end point, by analysing the disintegration behaviour of two tablet formulations in opaque media. In this study, the disintegration behaviour of one tablet formulation manufactured in-house, and Sybedia Flashtab placebo tablets in water, bovine, and human milk were characterised. A novel method is presented to characterise the disintegration process and to quantify the disintegration end points of the tablets in various media using load data generated by a texture analyser probe. The disintegration times in the different media were found to be statistically different (P<0.0001) from one another for both tablet formulations using one-way ANOVA. Using the Tukey post-hoc tes...Continue Reading

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Citations

Oct 1, 2016·Journal of Pharmaceutical Sciences·Rebekah L ScheuerleStephen E Gerrard
Nov 24, 2016·Pharmaceutical Development and Technology·Ahmad Ainurofiq, Syaiful Choiri
Mar 29, 2021·Advanced Drug Delivery Reviews·John P GleesonKathryn A Whitehead

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