Characterising the epigenome as a key component of the fetal exposome in evaluating in utero exposures and childhood cancer risk

Mutagenesis
Akram GhantousZdenko Herceg

Abstract

Recent advances in laboratory sciences hold a promise for a 'leap forward' in understanding the aetiology of complex human diseases, notably cancer, potentially providing an evidence base for prevention. For example, remarkable advances in epigenomics have an important impact on our understanding of biological phenomena and importance of environmental stressors in complex diseases. Environmental and lifestyle factors are thought to be implicated in the development of a wide range of human cancers by eliciting changes in the epigenome. These changes, thus, represent attractive targets for biomarker discovery intended for the improvement of exposure and risk assessment, diagnosis and prognosis and provision of short-term outcomes in intervention studies. The epigenome can be viewed as an interface between the genome and the environment; therefore, aberrant epigenetic events associated with environmental exposures are likely to play an important role in the onset and progression of different human diseases. The advent of powerful technologies for analysing epigenetic patterns in both cancer tissues and normal cells holds promise that the next few years will be fundamental for the identification of critical cancer- and exposure-ass...Continue Reading

References

Dec 8, 2004·Developmental Biology·Vincent L BironD Alan Underhill
Feb 15, 2005·Early Human Development·Mel Greaves
Feb 19, 2005·Nature Reviews. Cancer·Toshikazu Ushijima
Jun 22, 2005·Toxicology and Applied Pharmacology·Martyn T SmithPatricia A Buffler
Aug 17, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Christopher Paul Wild
Dec 22, 2005·Nature Reviews. Genetics·Andrew P FeinbergSteven Henikoff
May 3, 2006·Human Molecular Genetics·Pauline A Callinan, Andrew P Feinberg
Jan 27, 2007·International Journal of Epidemiology·Rebecca C BrownUNKNOWN International Childhood Cancer Cohort Consortium (I4C)
Mar 7, 2007·Nature Reviews. Genetics·Manel Esteller
Mar 21, 2007·Environmental Health Perspectives·Martin BelsonAdrianne Holmes
Mar 30, 2007·Nature Genetics·Daniel Zilberman
Apr 5, 2007·Nature Protocols·Romulo M BrenaChristoph Plass
Aug 3, 2007·Proceedings of the National Academy of Sciences of the United States of America·Dana C DolinoyRandy L Jirtle
Nov 14, 2007·American Journal of Human Genetics·Christine Ladd-AcostaAndrew P Feinberg
Jul 4, 2008·The New England Journal of Medicine·Peter D GluckmanKent L Thornburg
Sep 12, 2008·Annual Review of Pathology·Michael A Teitell, Pier Paolo Pandolfi
Apr 15, 2009·Biochimica Et Biophysica Acta·Ole AmmerpohlReiner Siebert
Feb 4, 2010·Nature Reviews. Genetics·Peter W Laird
Sep 21, 2010·Nature Biotechnology·Christoph BockAlexander Meissner
Oct 15, 2010·Nature Biotechnology·Stephan Beck
Oct 15, 2010·Nature Biotechnology·John S SatterleeHuck-Hui Ng
Oct 23, 2010·Science·Stephen M Rappaport, Martyn T Smith
Jan 25, 2011·Briefings in Functional Genomics·Iris Uribesalgo, Luciano Di Croce
Apr 22, 2011·Trends in Genetics : TIG·Aleksandar Milosavljevic
Jul 16, 2011·Epigenetics : Official Journal of the DNA Methylation Society·Zdenko Herceg, Thomas Vaissière
Sep 23, 2011·Epigenetics : Official Journal of the DNA Methylation Society·Melissa SuterKjersti M Aagaard-Tillery
Dec 17, 2011·PLoS Genetics·Michael J ZillerAlexander Meissner
Jan 5, 2012·Nature Reviews. Genetics·Robert Feil, Mario F Fraga
Jan 24, 2012·Cancer Letters·Ho-Sun Lee, Zdenko Herceg
Mar 9, 2012·Nature Biotechnology·David AdamsSpike Willcocks
Jun 8, 2012·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Stephen M Rappaport
Jun 22, 2012·Environmental Health : a Global Access Science Source·Robert BaroukiJerrold J Heindel
Aug 2, 2012·Environmental Health Perspectives·Bonnie R JoubertStephanie J London
Sep 14, 2012·Journal of Medical Genetics·Anika HüsingUNKNOWN BPC3
Feb 26, 2013·The Lancet Oncology·Ian MagrathScott C Howard
Mar 7, 2013·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Muin J KhourySheri D Schully
Apr 2, 2013·Cell·Hui Shen, Peter W Laird
May 7, 2013·Epigenetics : Official Journal of the DNA Methylation Society·Maria KipplerKarin Broberg
May 18, 2013·Environmental and Molecular Mutagenesis·Christopher P WildZdenko Herceg
Jun 12, 2013·Carcinogenesis·Zdenko HercegChristopher P Wild
Jun 13, 2013·Environmental Health Perspectives·Devin C KoestlerCarmen J Marsit

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Citations

Sep 16, 2015·Mutagenesis·Paolo Vineis
Jun 4, 2016·Environmental Health Perspectives·Kristine K DennisGary W Miller
Nov 23, 2018·Paediatric and Perinatal Epidemiology·Gabriella TikellisUNKNOWN International Childhood Cancer Cohort Consortium
Aug 25, 2017·International Journal of Cancer. Journal International Du Cancer·Zdenko HercegHector Hernandez-Vargas
Feb 13, 2016·Epigenomics·Srikant AmbatipudiZdenko Herceg
Sep 14, 2017·Molecular Diagnosis & Therapy·Eleni Stylianou
Nov 13, 2019·Proceedings of the National Academy of Sciences of the United States of America·Iradj SobhaniPhilippe J Sansonetti
Sep 15, 2019·Environmental Research·Alina-Andreea ZimtaIoana Berindan-Neagoe

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