Abstract
Laser Doppler Fluximetry (LDF) and iontophoresis of vasodilators have been combined to assess microvascular flow and vasodilator reactivity in humans for many years and their use established. However, traditional data analysis methods measure the magnitude of flux change but not its time-course, a factor that may be of importance in defining vascular health. The aim of this study was to develop and utilise a novel data analysis method using a standardised LDF and iontophoresis protocol, assessing time to peak vasodilation (Tmax). Endothelial-dependent and -independent vasodilator responses (using acetylcholine and sodium nitroprusside respectively) were measured in the perimalleolar region both supine and standing in patients with isolated superficial venous insufficiency (ISVI) (n=24) and controls (n=20), on two occasions. Tmax was measured at each post-iontophoretic period. Tmax was slower while standing and in patients with ISVI. There was no statistical difference in Tmax between visits for both groups (p>0.05), with coefficients of variation being between 20.2%-25.4%. ISVI, position and vasodilatory agents were significant determinants of Tmax. Tmax appears to be a reproducible method of assessing venous vasodilation, is n...Continue Reading
References
May 1, 1988·Microvascular Research·J K Wilkin
Jul 1, 1985·Microvascular Research·J Ninet, A Fronek
Feb 1, 1995·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·E WahlbergB Fagrell
May 1, 1994·European Journal of Vascular Surgery·E WahlbergJ Swedenborg
May 1, 1996·International Journal of Microcirculation, Clinical and Experimental·P M NettenT Thien
Jan 1, 1997·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·S A RayJ A Dormandy
Jun 1, 1997·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·A van der LugtH Pieterman
Jun 13, 1998·The Journal of Pharmacy and Pharmacology·R H Guy
Jul 5, 2002·World Journal of Surgery·Yoshihiro MoriwakiTakashi Suda
Feb 5, 2003·International Journal of Clinical Pharmacology and Therapeutics·S S JoshiA D Halpner
Apr 15, 2003·Journal of Applied Physiology·Brett J WongChristopher T Minson
Jun 24, 2003·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M KlonizakisR Donnelly
Mar 17, 2004·Microvascular Research·Erik J DroogFolke Sjöberg
Aug 30, 2005·Journal of Pharmacological and Toxicological Methods·Get Bee Yvonne-TeeAbdul Rashid Abdul Rahman
Dec 20, 2005·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M KlonizakisR Donnelly
Aug 1, 2006·Trends in Pharmacological Sciences·Jean-Luc CracowskiJohn R Halliwill
May 1, 2008·British Journal of Hospital Medicine·Umar Sadat, Michael Gaunt
Jun 3, 2008·European Journal of Applied Physiology·Helena Lenasi, Martin Strucl
Jan 1, 2013·Journal of Vascular Surgery. Venous and Lymphatic Disorders·Lindsay RobertsonF G R Fowkes