PMID: 9431456Feb 12, 1998Paper

Characteristic expression of high molecular mass heat shock protein HSP105 during mouse embryo development

Cell Structure and Function
T HatayamaK Shiota

Abstract

Expression of 105 k-Da heat shock protein (HSP105) during mouse embryo development was investigated. Although HSP105 was detected scarcely in mouse embryos at gestational day (GD) 8, its level of HSP105 increased markedly in the embryos from GD 9 to 11, and then decreased gradually by GD 14. In contrast, 70 k-Da heat shock cognate protein (HSC70) was detected at constantly high levels in embryo from GD 8 to 17 (before birth). The transient increase in level of HSP105 was observed in most embryonic tissues. Since the levels of HSP105 mRNA was detected at constantly high levels in the embryos between GD 8 and 12, the increased expression of HSP105 at GD 9 to 11 seemed to be regulated at posttranscriptional level. Immunohistochemically, HSP105 as well as HSC70 were localized in the cytoplasm and the nuclei of cells in various mouse embryonic tissues. After treatment of tissue sections with proteinase K, HSP105 but not HSC70 was also found to be localized in condensed cells and condensed bodies which showed the typical characteristics of apoptotic cells and apoptotic bodies at the interdigital regions of limbs. These findings suggest that HSP105 plays important roles during mouse embryo development.

Citations

Mar 17, 2009·Reproductive Biology and Endocrinology : RB&E·Jin-Xiang YuanYi-Xun Liu
Aug 16, 2002·European Journal of Biochemistry·Nobuyuki YamagishiTakumi Hatayama
Feb 9, 2010·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·John J Heikkila
May 23, 2015·The Journal of Reproduction and Development·Ryosuke SakumotoKosuke Iga
Jul 9, 2008·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·J GauleyJ J Heikkila
Jul 25, 2006·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Julie Gauley, John J Heikkila
Jul 24, 1998·Biochemical and Biophysical Research Communications·T HatayamaK Yasuda
Oct 30, 2014·Human & Experimental Toxicology·Zhengli YanTianbao Zhang
Jul 29, 2008·Stroke; a Journal of Cerebral Circulation·Junji NakamuraKazuhiro Nagata
Nov 30, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ayana KakihanaYuji Nakayama
Aug 30, 2002·The Journal of Biological Chemistry·Nicholas D E GreeneAndrew J Copp
Nov 30, 2018·Frontiers in Neuroscience·David J Miller, Patrice E Fort
Oct 26, 2001·Biochemical and Biophysical Research Communications·T HatayamaK Sakai
May 18, 2021·Frontiers in Cell and Developmental Biology·Babban JeeSubhradip Karmakar

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