Characteristic expression of HTLV-1 basic zipper factor (HBZ) transcripts in HTLV-1 provirus-positive cells.

Retrovirology
T UsuiShimeru Kamihira

Abstract

HTLV-1 causes adult T-cell leukemia (ATL). Although there have been many studies on the oncogenesis of the viral protein Tax, the precise oncogenic mechanism remains to be elucidated. Recently, a new viral factor, HTLV-1 basic Zip factor (HBZ), encoded from the minus strand mRNA was discovered and the current models of Tax-centered ATL cell pathogenesis are in conflict with this discovery. HBZs consisting of non-spliced and spliced isoforms (HBZ-SI) are thought to be implicated in viral replication and T-cell proliferation but there is little evidence on the HBZ expression profile on a large scale. To investigate the role of HBZ-SI in HTLV-1 provirus-positive cells, the HBZ-SI and Tax mRNA loads in samples with a mixture of infected and non-infected cells were measured and then adjusted by dividing by the HTLV-I proviral load. We show here that the HBZ-SI mRNA level is 4-fold higher than non-spliced HBZ and is expressed by almost all cells harboring HTLV-1 provirus with variable intensity. The proviral-adjusted HBZ-SI and Tax quantification revealed a characteristic imbalanced expression feature of high HBZ and low Tax expression levels in primary ATL cells or high HBZ and very high Tax levels in HTLV-1-related cell lines (cell...Continue Reading

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Citations

Nov 9, 2011·The Journal of Infectious Diseases·Estelle DouceronRenaud Mahieux
Oct 5, 2012·Journal of Virology·Sylvain LaverdureJean-Michel Mesnard
Dec 6, 2012·Leukemia Research and Treatment·Francesca RendeVincenzo Ciminale
Nov 19, 2008·Retrovirology·Amel B Bouzar, Luc Willems
Aug 16, 2008·Retrovirology·Mathieu BoxusLuc Willems
Aug 5, 2009·Retrovirology·Masao Matsuoka, Patrick L Green
Aug 14, 2009·Retrovirology·Rachel Van DuyneFatah Kashanchi
Feb 6, 2010·Retrovirology·Prabal BanerjeeGerold Feuer
Oct 5, 2010·PLoS Pathogens·Aidan MacnamaraBecca Asquith
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Feb 6, 2016·Viruses·Tiejun Zhao
Jun 19, 2010·Chemico-biological Interactions·Katerina Chlichlia, Khashayarsha Khazaie
Jul 6, 2010·Molecular Aspects of Medicine·Masao Matsuoka
Apr 23, 2013·Reviews in Medical Virology·Yorifumi Satou, Masao Matsuoka
Mar 17, 2016·Retrovirology·Guangyong MaMasao Matsuoka
Nov 28, 2012·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Pedro D OliveiraLourdes Farre

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Methods Mentioned

BETA
reverse-transcription PCR
PCR

Software Mentioned

Stat View

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