Characteristic genes in THP‑1 derived macrophages infected with Mycobacterium tuberculosis H37Rv strain identified by integrating bioinformatics methods

International Journal of Molecular Medicine
Yu-Wei ZhangFan Li

Abstract

Mycobacterium tuberculosis (M. tb) is a highly successful pathogen that has co‑existed with humans for 1,000's of years. As the cornerstone of the immune system, macrophages are a key part of innate immunity. They ingest and degrade foreign substances including aging cells and microorganisms, coordinate the inflammatory process, and are the first line of defense against M. tb infection. Recent advances in cellular mycobacteriology have indicated that M. tb uses an remarkably complex strategy to disrupt macrophage function, in order to counteract the antimicrobial mechanisms of the innate and adaptive immune responses, thereby achieving immune escape. With the popularity of microarray technology, a variety of public platforms have provided a variety of gene expression data associated with physiological and disease conditions. Meta‑analysis can systematically and quantitatively analyze multiple independent data concerning the same disease, greatly improving the statistical significance and credibility of the gene expression data analysis performed. In the present study, 6 microarray expression datasets of human acute monocytic leukemia THP‑1 cell line infected by M. tb H37Rv strain were collected from the GEO database. A total of...Continue Reading

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Datasets Mentioned

BETA
GSE57028
GSE89391

Methods Mentioned

BETA
PCA
confocal microscopy
GTPase

Software Mentioned

GraphPad Prism
Cytoscape
R package MetaDE
CluGO
roP
MCODE
tb
CentiScape
Search Tool for
MetaQC

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