Abstract
Agents targeting vascular endothelial growth factor (VEGF) have increasingly been used for the treatment of advanced malignancies, and have been found to induce renal thrombotic microangiopathy (TMA) and proteinuria. However, histomorphological changes in human biopsies in this setting and the underlying mechanism are not yet fully understood. Therefore, we collected renal biopsy cases with a history of aVEGF therapy to review and compare morphological kidney changes in this context. Renal biopsies of 15 patients who had received anti-VEGF (aVEGF) therapy evaluated between 2013 and 2017 at a single centre were morphologically characterised with light microscopy, electron microscopy, and immunohistochemistry (IgA, IgG, IgM, C1q, and C3), and compared with cases with acute TMA caused by atypical haemolytic-uraemic syndrome or hypertension. Morphological overlap with immune complex and cryoglobulinaemic membranoproliferative glomerulonephritis, diabetic glomerulopathy and pre-eclampsia-induced glomerulopathy are discussed. Segmental glomerular capillary microaneurysms and segmental hyalinosis were typical morphological features of aVEGF therapy-induced glomerular microangiopathy, whereas fibrin or platelet thrombi or fragmented er...Continue Reading
References
Jan 23, 2003·The Journal of Biological Chemistry·Hikaru SugimotoRaghu Kalluri
Aug 2, 2003·The New England Journal of Medicine·James C YangSteven A Rosenberg
Jun 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David H JohnsonFairooz Kabbinavar
Nov 23, 2005·Oncology·Michael S Gordon, David Cunningham
Jan 27, 2006·Journal of the American Society of Nephrology : JASN·Vera EreminaSusan E Quaggin
Aug 18, 2006·Journal of the American Society of Nephrology : JASN·Raghu Kalluri
Dec 26, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hassane IzzedineOlivier Rixe
Jan 31, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Betsy A GeorgeRobert Toto
Jan 31, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Xiaolei ZhuChirag R Parikh
Feb 3, 2007·The Lancet Oncology·Carlos FrangiéDominique Nochy
Apr 26, 2007·Nature Clinical Practice. Nephrology·Daniel RonconeBrad H Rovin
Jul 31, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Hassane IzzedineGilbert Deray
Sep 25, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E KapiteijnH Gelderblom
Mar 14, 2008·The New England Journal of Medicine·Vera EreminaSusan E Quaggin
Jun 13, 2008·Kidney International·M Barry StokesVivette D D'Agati
Dec 5, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Guillaume BolléeBertrand Knebelmann
Jun 12, 2010·Journal of the American Society of Nephrology : JASN·Shenhong WuXiaolei Zhu
Apr 16, 2011·Journal of Pregnancy·Janina Müller-Deile, Mario Schiffer
Sep 27, 2013·Kidney International·Hassan IzzedineDjillali Sahali
Dec 5, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Cécile VigneauNathalie Rioux-Leclercq
Dec 24, 2013·Seminars in Arthritis and Rheumatism·Michael H Rosove
Aug 5, 2014·Human Pathology·Joichi UsuiSurya V Seshan
Aug 15, 2014·The New England Journal of Medicine·James N George, Carla M Nester
Dec 17, 2014·Medicine·Hassan IzzedineJean Charles Soria
May 7, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Hassan Izzedine, Mark A Perazella
Citations
Jul 7, 2019·Medicine·Teruhiro FujiiKosaku Nitta
Apr 13, 2020·CEN Case Reports·Masataka HasegawaYugo Shibagaki
Jan 13, 2019·BMC Nephrology·Ryo YamadaKiyoshi Mori
Mar 9, 2019·International Journal of Toxicology·Zaher A Radi
Jan 15, 2020·Case Reports in Nephrology·F TouzaniA Pozdzik
Jul 19, 2019·Frontiers in Immunology·Amélie LeursLouis Terriou
Jul 10, 2020·CEN Case Reports·Madoka MorimotoYuko Ono
Mar 9, 2019·BMC Nephrology·Shoko OchiaiShouichi Fujimoto
Sep 5, 2020·BioMed Research International·Tianbiao ZhouKai Hong
Dec 22, 2020·Terapevticheskiĭ arkhiv·K S GrechukhinaT N Krasnova
Apr 29, 2021·CEN Case Reports·Shinichi MizunoToshinobu Sato
Jun 12, 2021·Clinical and Experimental Nephrology·Masatoyo OzawaNaoto Takahashi
Sep 3, 2021·Physiological Reports·Akimasa AsaiYasuhiko Ito