Characteristic pattern of chromosomal gains and losses in marginal zone B cell lymphoma detected by comparative genomic hybridization

Leukemia
J DierlammA Hagemeijer

Abstract

Marginal zone B cell lymphoma (MZBCL) represents a distinct subtype of B cell non-Hodgkin's lymphoma, which has been recently recognized and defined as a disease entity. We investigated 25 cases (18 at primary diagnosis and seven during the course of disease) of MZBCL by comparative genomic hybridization (CGH) and compared these results with cytogenetic, fluorescence in situ hybridization (FISH), and Southern blot data. Twenty of the 25 cases (80%) showed gains (total 49) or losses (total 15) of genetic material. In extranodal, nodal, and splenic MZBCL, material of chromosomes 3 (52% of cases), 18 (32%), X (24%), and 1q (16%) was most frequently gained, whereas losses predominantly involved chromosomes 17 (16%) and 9 (12%). High-level amplifications involving the regions 18q21-23 and 18q21-22, respectively, were detected in two cases. Gains of chromosomes 1q and 8q and losses of chromosome 17 or 17p occurred more frequently in relapsed or progressive lymphomas. For all of the frequently affected chromosomes, CGH allowed narrowing of the relevant subregions including 3q21-23, 3q25-29 and 18q21-23. By Southern blot analysis, the BCL2, BCL6, and CMYC proto-oncogenes were found to be a part of the over-represented regions in two ca...Continue Reading

Citations

Apr 29, 1998·Genes, Chromosomes & Cancer·O MonniS Knuutila
Sep 29, 1999·Genes, Chromosomes & Cancer·E Callet-BauchuP Felman
May 8, 2000·Hematological Oncology·J DierlammD K Hossfeld
Jan 25, 2002·Genes, Chromosomes & Cancer·Sukvarsha MehraR S K Chaganti
Jul 10, 2003·Gastroenterology·Virginie VerkarreIsabelle Radford-Weiss
Jun 20, 2002·Cancer Genetics and Cytogenetics·Stéphanie StruskiPascale Cornillet-Lefebvre
Mar 10, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F WillekeR Ridder
Jan 19, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Xavier SagaertChristiane De Wolf-Peeters
Dec 13, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Xavier SagaertChristiane De Wolf-Peeters
Feb 24, 2001·Cell Research·T L Rothstein
Mar 23, 1999·British Journal of Haematology·A M Gruszka-WestwoodD Catovsky
Apr 16, 2002·Histopathology·B Maes, C De Wolf-Peeters
Nov 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·Gotz R A EhrhardtMax D Cooper
Jul 28, 2006·The American Journal of Dermatopathology·Arnaud de la FouchardiereFrançoise Berger
Jul 16, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Haytham KhouryDouglas E Horsman
May 18, 2011·Current Opinion in Hematology·Catherine ThieblemontJosette Brière
Jan 16, 2009·The American Journal of Surgical Pathology·Dong ChenAhmet Dogan
Jan 30, 2004·Molecular and Cellular Biology·Zhongdong HuangJ Michael Bishop
Feb 14, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Itziar SalaverriaElias Campo
Oct 1, 2011·PloS One·Cristina RobledoJesús M Hernández
Dec 14, 2006·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Jean-Louis DargentPierre Heimann
May 11, 2012·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·David M ParhamCheryl M Coffin
Jul 3, 2013·Haematologica·Michiel van den Brand, J Han J M van Krieken
Feb 8, 2003·The Lancet Oncology·Catherine ThieblemontBertrand Coiffier
Oct 8, 1999·Leukemia & Lymphoma·F BertoniE Zucca
Jun 1, 1999·Leukemia & Lymphoma·O MonniS Knuutila
Apr 12, 2003·Leukemia & Lymphoma·Jose A Martinez-ClimentJavier García-Conde
Apr 17, 2004·The Journal of Investigative Dermatology·Tanja C FischerHolger Tönnies
May 17, 2011·American Journal of Clinical Pathology·Michael SidiropoulosZeina Ghorab
Dec 17, 2009·Human Pathology·Scott D DufresneSteven H Swerdlow
Jul 2, 2002·American Journal of Clinical Pathology·Sara A KentLoAnn C Peterson

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