Characteristic patterns of EEG oscillations in sheep (Ovis aries) induced by ketamine may explain the psychotropic effects seen in humans.

Scientific Reports
A U Nicol, A J Morton

Abstract

Ketamine is a valuable anaesthetic and analgesic that in recent years has gained notoriety as a recreational drug. Recently, ketamine has also been proposed as a novel treatment for depression and post-traumatic stress disorder. Beyond its anaesthetic actions, however, the effects of ketamine on brain activity have rarely been probed. Here we examined the cortical electroencephalography (EEG) response to ketamine of 12 sheep. Following ketamine administration, EEG changes were immediate and widespread, affecting the full extent of the EEG frequency spectrum measured (0-125 Hz). After recovery from sedation during which low frequency activity dominated, the EEG was characterised by short periods (2-3 s) of alternating low (<14 Hz) and high (>35 Hz) frequency oscillation. This alternating EEG rhythm phase is likely to underlie the dissociative actions of ketamine, since it is during this phase that ketamine users report hallucinations. At the highest intravenous dose used (24 mg/kg), in 5/6 sheep we observed a novel effect of ketamine, namely the complete cessation of cortical EEG activity. This persisted for up to several minutes, after which cortical activity resumed. This phenomenon is likely to explain the 'k-hole', a state o...Continue Reading

References

Jan 1, 1976·Acta Anaesthesiologica Scandinavica·I Rosén, M Hägerdal
Feb 24, 2001·Journal of Psychoactive Drugs·K L Jansen
Feb 1, 2005·Anesthesiology·M Sesmu ArbousDiederick E Grobbee
Jan 11, 2008·Thalamus & Related Systems·Anton Sirota, György Buzsáki
Oct 16, 2010·Biological Psychiatry·Hannah L MorganPaul C Fletcher
May 31, 2013·Journal of the South African Veterinary Association·T Brighton Dzikiti
Jan 1, 2013·Journal of Huntington's Disease·A Jennifer Morton, David S Howland
Feb 6, 2015·Therapeutic Advances in Psychopharmacology·Hannah SteedsJames M Stone
Apr 8, 2015·Annals of Cardiac Anaesthesia·Michael MazzeffiChristopher Paciullo
Jul 15, 2015·Journal of Trauma & Dissociation : the Official Journal of the International Society for the Study of Dissociation (ISSD)·Basant PradhanTapan Parikh
Aug 21, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Suresh D MuthukumaraswamyNeeraj Saxena
Mar 31, 2016·Clinical Pharmacokinetics·Marko A PeltoniemiTeijo I Saari
May 15, 2016·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Oluwaseun AkejuPatrick L Purdon
Jun 23, 2016·Depression and Anxiety·Sean Sassano-HigginsMark Gold
Sep 15, 2016·Journal of Anaesthesiology, Clinical Pharmacology·Nalini VadiveluAlan David Kaye
Apr 6, 2017·Mammalian Genome : Official Journal of the International Mammalian Genome Society·S L Eaton, T M Wishart
Jun 2, 2018·Methods in Molecular Biology·A J Morton
Nov 9, 2018·Frontiers in Behavioral Neuroscience·Jessica E MonkCaroline Lee
Mar 8, 2019·Neuron·John H KrystalRonald S Duman

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Methods Mentioned

BETA
sedation
transgenic
dissection

Software Mentioned

SPSS

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