Characteristic properties of muscular-derived extracellular matrix and its application in rat abdominal wall defects

Regenerative Medicine
Zhi YangYan Gu

Abstract

To investigate the behavior of porcine-derived decellularized muscular matrix (DMM) in vitro and compare the performance of this biological mesh with that of acellular dermal matrix from pig in a full abdominal wall defect model. To describe the in vitro properties of the DMM scaffold with extracellular matrix histological analysis, growth factor quantification and scanning electron microscopy analysis. To compare structural and functional remodeling between acellular dermal matrix and DMM implants in a rodent full abdominal wall defect model. The results demonstrated that cellular components were effectively removed in the DMM scaffold, which also maintained a 3D architecture, biochemical components and strong mechanical properties. In vivo experiments confirm that the DMM mesh could promote remodeling and reconstruction of functional skeletal muscle tissue.

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Citations

Sep 22, 2019·International Journal of Molecular Sciences·Kevin DzoboAdetola Adesida
Jan 18, 2021·Surgery·Joseph F BuellPleasant Hooper

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Methods Mentioned

BETA
protein
enzyme-linked immunosorbent assay
scanning electron microscopy
force measurements

Software Mentioned

SPSS
MultiGauge

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