Characteristics and circumstances of synthetic cannabinoid-related death

Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists
Shane DarkeJulia Lappin

Abstract

Introduction: Synthetic cannabinoids are an emerging clinical and public health concern. The current study aimed to determine: (1) The characteristics and circumstances of death of all recorded cases of synthetic cannabinoid-related sudden or unnatural death in Australia, (2) The toxicology of cases and (3) Their major organ pathology. Methods: Retrospective study of all cases in Australia in which synthetic cannabinoid use was a mechanism contributory to death (n  =  55) retrieved from the National Coronial Information System (2000-2017). Information was collected on cause of death, demographics, drug use history, circumstances of death, toxicology and major organ pathology. Results: The mean age was 37.2 years and 91.1% were male. Causes of death comprised of accidental toxicity (38.2%), accidental toxicity/cardiovascular disease (9.1%), natural disease (20.0%), suicide (10.9%) and traumatic accident (10.9%). The most common clinical presentation proximal to death was sudden collapse (25.5%). Cardiovascular disease was prominent: severe atherosclerosis (20.0%), myocardial replacement fibrosis (18.0%), cardiomegaly (12.0%). The most frequent synthetic cannabinoids were the indazolecarboxemides (61.8%), most commonly AB-CHMINAC...Continue Reading

References

Oct 10, 2012·Drug and Alcohol Review·Monica J BarrattSimon Lenton
Dec 14, 2012·Journal of Child and Adolescent Psychopharmacology·Felecia N Jinwala, Mayank Gupta
Jul 5, 2013·Journal of Forensic Sciences·Amy L PattonJeffery H Moran
Aug 24, 2013·Journal of Analytical Toxicology·Robert KronstrandArne Eklund
Nov 12, 2013·Neurology·Melissa J FreemanW Scott Burgin
May 31, 2014·Journal of Analytical Toxicology·George BehonickChady Meroueh
Jul 30, 2014·Journal of Forensic and Legal Medicine·Pradeep K DebataManish Kumath
Sep 16, 2014·Drug and Alcohol Dependence·Marisol S CastanetoMarilyn A Huestis
Mar 17, 2015·Forensic Science, Medicine, and Pathology·Dimitri GerostamoulosNoel W Woodford
May 17, 2015·Forensic Science International : Synergy·Kevin G ShanksGeorge Behonick
Jul 6, 2015·The American Journal of Emergency Medicine·Brett SweeneyGetaw Worku Hassen
Aug 11, 2015·Forensic Toxicology·Koutaro HasegawaOsamu Suzuki
Sep 1, 2015·Neurology·David Z RoseW Scott Burgin
Oct 31, 2015·The Journal of Emergency Medicine·Jonathan Von Der HaarGetaw Worku Hassen
Nov 17, 2015·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Robert J TaitSimon Lenton
Jan 23, 2016·Forensic Science International : Synergy·Laura M LabayBarry K Logan
Feb 18, 2016·Drug and Alcohol Dependence·Rachel SutherlandRaimondo Bruno
Mar 5, 2016·Forensic Science International : Synergy·Piotr Adamowicz
Mar 16, 2016·Journal of Analytical Toxicology·Dimitri GerostamoulosOlaf H Drummer
Mar 28, 2016·Forensic Science International : Synergy·Kevin G Shanks, George S Behonick
Apr 16, 2016·Addiction·Shane Darke, Johan Duflou
Sep 10, 2016·Journal of Clinical Pharmacology·C Michael White
Nov 26, 2016·The International Journal on Drug Policy·Monica J BarrattKari Lancaster
Dec 16, 2016·The New England Journal of Medicine·Axel J AdamsRoy Gerona
Jan 27, 2017·BMJ : British Medical Journal·Derek K TracyDavid Baumeister
Feb 6, 2017·The International Journal on Drug Policy·Rachel SutherlandMonica J Barratt
May 2, 2017·Journal of Analytical Toxicology·Barry K LoganMarilyn A Huestis
May 13, 2017·Journal of Studies on Alcohol and Drugs·Cath ChapmanMaree Teesson
Aug 9, 2017·Drug and Alcohol Dependence·Shane DarkeSharlene Kaye
Nov 15, 2017·Forensic Science International : Synergy·V AngererJ Pietsch
Dec 31, 2017·BMC Nephrology·Kanaan MansoorZeid J Khitan
Aug 15, 2018·Handbook of Experimental Pharmacology·Samuel D Banister, Mark Connor
May 10, 2019·Medicine, Science, and the Law·Phoebe SharpStephen R Morley

❮ Previous
Next ❯

Citations

Apr 7, 2020·Archives of Toxicology·Dino Luethi, Matthias E Liechti
Dec 8, 2020·Journal of Developmental Origins of Health and Disease·Oyekoya T AyonrindeOyekunle K Ayonrinde
Jan 27, 2021·Pharmacology, Biochemistry, and Behavior·Eef L TheunissenJohannes G Ramaekers
Nov 14, 2020·Forensic Science, Medicine, and Pathology·Marianne TiemensmaSteven Karch
Jan 9, 2021·Therapeutic Advances in Psychopharmacology·Abu ShafiDerek K Tracy
Mar 21, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Astrid Coronado-ÁlvarezEric Murillo-Rodríguez
Jul 28, 2021·Journal of Cannabis Research·Melissa A JacksonAdrian J Dunlop
Aug 4, 2021·The International Journal on Drug Policy·Shane DarkeJulia Lappin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.