Characteristics and clinical course of type 1 diabetes mellitus related to anti-programmed cell death-1 therapy

Diabetology International
Megu Yamaguchi Badenconsultation of the Japan Diabetes Society Committee on Type 1 Diabetes Mellitus Research

Abstract

We conducted a national survey to clarify the characteristics and clinical course of type 1 diabetes related to anti-programmed cell death-1 therapy. We analyzed the detailed data of 22 patients that were collected using a Japan Diabetes Society survey and a literature database search. Among the 22 patients, 11 (50.0%) met the criteria for fulminant type 1 diabetes and 11 (50.0%) met the criteria for acute-onset type 1 diabetes. The average patient age was 63 years. The mean duration between the date of the first anti-PD-1 antibody injection and development of type 1 diabetes was 155 days and ranged from 13 to 504 days. Flu-like symptoms, abdominal symptoms, and drowsiness were observed in 27.8, 31.6, and 16.7% patients, respectively. Mean ± standard deviation or median (first quartile-third quartile) glucose levels, HbA1c levels, urinary C-peptide immunoreactivity levels, and fasting serum C-peptide immunoreactivity levels were 617 ± 248 mg/dl, 8.1 ± 1.3%, 4.1 (1.4-9.4) μg/day, and 0.46 (0.20-0.70) ng/ml, respectively. Seventeen of 20 patients (85.0%) developed ketosis, and 7 of 18 patients (38.9%) developed diabetic ketoacidosis. Ten of 19 patients (52.6%) showed at least one elevated pancreatic enzyme level at the onset and ...Continue Reading

References

Jul 29, 2003·Diabetes Care·Akihisa ImagawaHideichi Makino
Dec 21, 2006·Nature Clinical Practice. Endocrinology & Metabolism·Toshiaki Hanafusa, Akihisa Imagawa
Sep 16, 2008·Diabetes Research and Clinical Practice·Akihisa ImagawaHideichi Makino
Jun 25, 2009·Diabetes Care·Andreas NeuUNKNOWN DPV Initiative and the German BMBF Competency Network for Diabetes Mellitus
Jul 1, 2009·Diabetes Care·Abbas E KitabchiJoseph N Fisher
Jul 31, 2013·Lancet·Mark A AtkinsonAaron W Michels
Feb 20, 2012·Journal of Diabetes Investigation·Atsunori KashiwagiUNKNOWN Committee on the Standardization of Diabetes Mellitus‐Related Laboratory Testing of Japan Diabetes Society
Apr 4, 2015·Science·Padmanee Sharma, James P Allison
Jan 15, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J M MichotO Lambotte
Apr 18, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Lars HofmannLucie M Heinzerling
Nov 3, 2016·Journal of Diabetes Investigation·Masahide OkamotoHirotaka Shibata
Jun 15, 2016·The Tohoku Journal of Experimental Medicine·Yuka MiyoshiYu Oyama
Jun 24, 2016·The Journal of Dermatology·Yukiko TeramotoAkifumi Yamamoto
Oct 4, 2016·International Journal of Hematology·Wataru MunakataKensei Tobinai
Dec 27, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Yuko UsuiKoichi Goto
Jun 22, 2017·Cancer Immunology, Immunotherapy : CII·Marie-Léa GauciJean-François Gautier
Nov 4, 2017·Journal of Diabetes Investigation·Ryo KumagaiHiroaki Yagyu
Feb 15, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Julie R BrahmerUNKNOWN National Comprehensive Cancer Network
Jul 5, 2016·Diabetology International·Hiroshi IkegamiShinsuke Noso
Dec 29, 2015·Diabetology International·Megu Yamaguchi BadenToshiaki Hanafusa

❮ Previous
Next ❯

Citations

Feb 10, 2019·Journal of Diabetes Investigation·Yui ShibayamaTatsuya Atsumi
Oct 7, 2019·Journal of Diabetes Investigation·Masaaki MiyauchiMasafumi Fukagawa
Jul 3, 2020·Journal of Clinical Medicine·Naoko OkuraKoichi Takayama
Jun 17, 2020·Diabetes/metabolism Research and Reviews·Zhenjiang ZhengXubao Liu
Jul 12, 2020·The Journal of Clinical Endocrinology and Metabolism·Daisuke ChujoMasayuki Shimoda
May 22, 2019·The Journal of Clinical Endocrinology and Metabolism·Mikako TakitaTetsuro Kobayashi
Jul 25, 2020·Ear, Nose, & Throat Journal·Alex J F TampioBrian D Nicholas
Oct 23, 2020·Diabetology International·Yoichi Oikawa, Akira Shimada
Oct 23, 2020·Diabetology International·Toshiaki Hanafusa
Oct 23, 2020·Diabetology International·Akihisa Imagawa, Megumi Tachibana
Apr 4, 2021·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Imke GrimmelmannUNKNOWN German Dermatooncology Group (DeCOG)
Jun 1, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Koki ShimadaHiroaki Miyata

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.