Characteristics and determinants of adiposity in pediatric cancer survivors.

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Tracie L MillerSteven E Lipshultz

Abstract

Adiposity and the diseases associated with it, including cardiovascular disease, are emerging long-term complications of pediatric cancer survivors. Direct evaluations of adiposity and comparisons to contemporary controls that can differentiate recent trends in obesity from cancer-related treatments and sequelae are limited. We evaluated demographic, treatment, lifestyle, and endocrine factors at the time of dual-energy X-ray absorptiometry testing in 170 non-Hispanic white survivors and 71 sibling controls, and compared three measures of adiposity [body mass index (BMI), total body fat, and trunk fat]. For the survivors alone, we determined factors independently associated with BMI and body fat. Survivors were at 12 years since diagnosis; 58% had leukemia or lymphoma. BMI did not differ between groups. Among males, body fat was greater in survivors than in controls (25.8% versus 20.7%; P = 0.007), as was trunk fat (26.7% versus 21.3%; P = 0.008). Total or trunk fat did not differ among females. Cholesterol, triglycerides, low-density lipoprotein cholesterol, and television viewing hours were higher among male survivors than in controls. Independent factors associated with higher BMI and total and trunk fat included any cranial...Continue Reading

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Citations

Jan 12, 2011·Pediatric Cardiology·Barry H TrachtenbergSteven E Lipshultz
Jul 27, 2007·Cardiovascular Toxicology·Rebecca E Scully, Steven E Lipshultz
Oct 30, 2013·Nature Reviews. Clinical Oncology·Steven E LipshultzTracie L Miller
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Dec 19, 2019·Nutrients·Ewa BargBernarda Kazanowska
Mar 11, 2020·Cardio-Oncology·Neha BansalSteven E Lipshultz

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