Characteristics and Discrepancies in Acute-on-Chronic Liver Failure: Need for a Unified Definition

PloS One
Tae Yeob KimKorean Acute-on-Chronic Liver Failure Study Group

Abstract

To investigate the prevalence, mortalities, and patient characteristics of Acute-on-chronic liver failure (ACLF) according to the AARC (Asian Pacific Association for the Study of the Liver ACLF Research Consortium) and European Association for the Study of the Liver CLIF-C (Chronic Liver Failure Consortium) definitions. We collected retrospective data for 1470 hospitalized patients with chronic liver disease (CLD) and acute deterioration between January 2013 and December 2013 from 21 university hospitals in Korea. Of the patients assessed, the prevalence of ACLF based on the AARC and CLIF-C definitions was 9.5% and 18.6%, respectively. The 28-day and 90-day mortality rates were higher in patients with ACLF than in those without ACLF. Patients who only met the CLIF-C definition had significantly lower 28-day and 90-day survival rates than those who only met the AARC definition (68.0% vs. 93.9%, P<0.001; 55.1% vs. 92.4%, P<0.001). Among the patients who had non-cirrhotic CLD, the 90-day mortality of the patients with ACLF was higher than of those without ACLF, although not significant (33.3% vs. 6.0%, P = 0.192). Patients with previous acute decompensation (AD) within 1- year had a lower 90-day survival rate than those with AD mo...Continue Reading

References

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Citations

Apr 18, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ângelo Zambam de Mattos, Angelo Alves de Mattos
Apr 25, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jasmohan S BajajFlorence Wong
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Jun 10, 2016·Nature Reviews. Disease Primers·Vicente ArroyoBernd Schnabl
Oct 19, 2019·Journal of Clinical Medicine·Eileen L YoonOn Behalf Of The Korean Acute-On-Chronic Liver Failure KACLiF Study Group
Aug 26, 2020·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Do Seon Song
Sep 17, 2020·Clinical and Molecular Hepatology·Jongbeom ShinSoung Won Jeong
Oct 3, 2020·Clinical Liver Disease·Alberto Queiroz Farias, Paulo Lisboa Bittencourt
May 28, 2020·The New England Journal of Medicine·Vicente ArroyoRajiv Jalan
Oct 14, 2020·BMC Gastroenterology·Guilherme Rossi Assis-MendonçaLarissa Bastos Eloy da Costa
Dec 2, 2020·Nature Reviews. Gastroenterology & Hepatology·Jonel TrebickaManimozhiyan Arumugam
Jan 4, 2021·Digestive Diseases and Sciences·Caroline BaldinGustavo Pereira
Nov 19, 2020·JHEP Reports : Innovation in Hepatology·Giacomo ZaccheriniRichard Moreau
May 28, 2021·Journal of Hepatology·Richard MoreauPatrick S Kamath
Aug 17, 2021·Canadian Journal of Gastroenterology & Hepatology·Fernando Comunello SchacherMario Reis Álvares-da-Silva

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