Characteristics and follow-up of metastatic breast cancer in Ethiopia: A cohort study of 573 women

The Breast : Official Journal of the European Society of Mastology
Christina Mirjam WeinerEva Johanna Kantelhardt

Abstract

There is little information on characteristics, treatment and outcome of metastatic breast cancer (mBC) patients in low-income countries. This study aims to describe mBC in the setting of Ethiopia. A retrospective cohort study was conducted among all female mBC patients from the only oncologic hospital in Addis Ababa 01/2006 to 12/2010. Time between first metastasis and known death or loss to follow-up for more than six months as surrogate for death were used for Cox proportional hazards model. A total of 573 patients were included; 188 (32.8%) women with de novo mBC (dnmBC) and 385 women with recurrent mBC (rmBC). The average age at time of first metastasis was 43.7 (standard deviation 11.9) years with an average survival probability of twelve months. Negative hormone receptor status, only present in 29% (Hazard ratio HR = 2.28 [95% confidence interval CI 1.56-3.32] p < 0.001), and grade 3 (HR = 1.72 [95% CI 1.15-2.55] p = 0.008) had significant influence on survival. Patients with initial bone metastasis (HR = 0.63 [95% CI 0.48-0.83] p = 0.001) had best chances of survival compared to more common initial visceral metastasis. About 35% of the patients received chemotherapy and 30.5% were on endocrine therapy. The lower surviva...Continue Reading

Citations

Apr 27, 2019·BMC Cancer·Biniyam Tefera DeressaDaniel Rauch
Sep 20, 2020·Breast Cancer Research and Treatment·Alem GebremariamAhmedin Jemal
Mar 23, 2021·Clinical Breast Cancer·Karen DailyAlexandra Thomas
Jun 15, 2021·Breast Cancer Research and Treatment·Yoanna S PumpalovaAlfred I Neugut
Jun 19, 2021·Annals of Biomedical Engineering·Alyssa D SchwartzCourtney C Babbitt
Nov 6, 2021·Journal of Surgical Oncology·Komla Séna AmouzouAngela Caroli

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.