Nov 27, 2004

Characteristics and immediate outcome of childhood meningitis treated in the pediatric intensive care unit

Intensive Care Medicine
Folafoluwa O Odetola, Susan L Bratton

Abstract

To describe patient characteristics, use of technology and mortality in children with meningitis admitted to the pediatric intensive care unit (PICU). Retrospective cohort study. Fifteen US PICUs. All admissions with a diagnosis of meningitis between 1995 and 2000 in the Pediatric Intensive Care Unit Evaluations (PICUEs) database. Of 559 patients with meningitis, 58% were male. The median age was 19 months and the median length of PICU stay was 2 days. The crude PICU mortality rate was 7%. Three hundred thirty-four (60%) patients had bacterial meningitis. Non-survivors had significantly higher Pediatric Risk of Mortality (PRISM) III scores and also constituted a larger proportion of the patients with bacterial meningitis, coma and shock upon PICU admission. The use of invasive devices was higher among non-survivors, patients with bacterial meningitis or those who were in coma or shock upon PICU admission. There was significant variation in the use of intracranial pressure (ICP) monitors by coma status and by institution. In multivariate analysis, patients had 1.26 higher odds of mortality for each unit increase in PRISM III score (odds ratio 1.26, 95% confidence interval: 1.19-1.34), while adjusting for other variables. In a la...Continue Reading

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References

Mentioned in this Paper

Pediatric Intensive Care Unit
Coma (genus)
Multicenter Trials
Severity of Illness Index
Logistic Regression
Apraxia, Oculomotor, Cogan Type
Intracranial Pressure
Mechanical Ventilation
COMA
Pachymeningitis

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