PMID: 1199694Oct 1, 1975Paper

Characteristics and limits of tolerance in repeated subarachnoid hemorrhage in dogs

Acta Neurologica Scandinavica
L SteinerN N Zwetnow

Abstract

The effects of repeated subarachnoid hemorrhages have been investigated experimentally in dogs. The main objectives were to determine the tolerance to repeated hemorrhage and to study the changes occurring during the repeated bleeds, in intracranial pressure, EEG, ECG, systemic arterial pressure and respiration. The natural course of an intracranial hemorrhage was simulated by shunting blood from a femoral artery through a drop recorder into five different sites in the craniospinal system: the chiasmatic cistern, a lateral ventricle, the cisterna magna, the lumbar subarachnoid space and into the cerebral tissue of the left frontal lobe. The hemorrhage was allowed to continue until it stopped spontaneously. Each bleed resulted in a transient rise in intracranial pressure to the level of the arterial pressure, followed by a return to a steady state value. The time taken for the attainment of the steady state was increasingly prolonged. The final steady state pressure increased with each bleed. Ultimately, a stage was reached where the hemorrhage resulted in a sustained high pressure at the level of the arterial blood pressure, producing failure of vital functions and an irreversibly isoelectric electroencephalogram. The average n...Continue Reading

References

Oct 1, 1975·Acta Neurologica Scandinavica·L SteinerN N Zwetnow
Jan 1, 1973·Acta Neurologica Scandinavica·J LöfgrenN N Zwetnow
May 1, 1972·Journal of Neurosurgery·H Nornes, B Magnaes
Jan 1, 1967·Acta Neurologica Scandinavica·J H Trumpy
May 1, 1954·Circulation·G E BURCHJ A ABILDSKOV

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Citations

Jan 1, 1992·Acta neurochirurgica·J R OrlinA Bjørneboe
Jan 1, 1983·Acta neurochirurgica·N N ZwetnowS Häkanson
Dec 7, 2007·Neurocritical Care·Michael Lucas JamesDaniel T Laskowitz
Oct 1, 1975·Acta Neurologica Scandinavica·L SteinerN N Zwetnow
Oct 1, 1988·Journal of Neurology, Neurosurgery, and Psychiatry·H Steinmetz, W Hassler
Jun 1, 1982·Journal of Neurosurgery·B Voldby, E M Enevoldsen
Dec 1, 1982·Journal of Neurosurgery·A Hijdra, J van Gijn
Apr 1, 1994·Journal of Neurosurgery·P W McCormickR F Spetzler
Dec 1, 1996·Journal of Neurosurgery·K E JakobssonL Pellettieri
Jun 9, 2006·Neurological Research·Fatima A Sehba, Joshua B Bederson
Dec 26, 2008·Neurological Research·Elena TitovaJiping Tang
Oct 19, 2014·Translational Stroke Research·Serge MarbacherJavier Fandino
Jan 1, 1993·Acta neurochirurgica·N N ZwetnowN Tajsic
Aug 24, 2010·British Journal of Neurosurgery·Serge MarbacherNeil D Kitchen
Mar 15, 2012·Progress in Neurobiology·Fatima A SehbaJohn H Zhang
Nov 22, 2011·World Neurosurgery·Robert G WhitmoreSherman C Stein
Jul 24, 2013·Stroke Research and Treatment·Fatima A Sehba, Ryszard M Pluta
Jun 20, 2017·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Jing LuDezhi Kang
Dec 9, 2015·Laboratory Animals·Anders Backer-GrøndahlLars Marius Ytrebø
Jan 1, 1981·Stroke; a Journal of Cerebral Circulation·A D MendelowB H Eidelman

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