Characteristics and Outcome in Acute Coronary Syndrome Patients with and without Established Modifiable Cardiovascular Risk Factors: Insights from the Nationwide AMIS Plus Registry 1997-2010

Cardiology
Paul ErneDragana Radovanovic

Abstract

Little is known about patients without known modifiable risk factors presenting initially with acute coronary syndrome (ACS). This study assessed baseline characteristics and outcomes of ACS patients with and without the known modifiable risk factors arterial hypertension, dyslipidemia, obesity, smoking or diabetes. All ACS patients enrolled in the AMIS Plus Registry between 1997 and 2010 were analyzed until hospital discharge; a subgroup was re-assessed at the 1-year follow-up. Outcome measures were in-hospital mortality and major adverse cardiac or cerebrovascular events (MACCE) defined as a composite outcome of mortality, re-infarction and cerebrovascular events. Of 33,306 patients, 2,125 (6.4%) had none of these modifiable risk factors. They were older (males), had less moderate or severe comorbidities and were more frequently in Killip class I on admission. Treatment of ACS patients with or without modifiable risk factors was similar with regard to interventional therapies and use of antiplatelet agents. In-hospital mortality was lower in patients without modifiable risk factors but in-hospital MACCE and 1-year survival was similar. Lack of modifiable risk factors was an independent predictor of lower in-hospital mortality...Continue Reading

References

Dec 6, 2006·Annals of Emergency Medicine·Jin H HanUNKNOWN EMCREG i*trACS Investigators
Nov 6, 2007·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Ian GrahamUNKNOWN European Atherosclerosis Society (EAS)
Oct 24, 2007·European Heart Journal·Kristian ThygesenUNKNOWN Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction
Jan 9, 2008·Journal of the American Geriatrics Society·Andreas W SchoenenbergerUNKNOWN Acute Myocardial Infarction in Switzerland Plus Investigators
Jan 24, 2008·Circulation·Ralph B D'AgostinoWilliam B Kannel
Nov 5, 2008·Annals of Internal Medicine·Raban V JegerUNKNOWN AMIS Plus Registry Investigators
Nov 26, 2008·The American Journal of Medicine·Philip UrbanUNKNOWN AMIS Plus Investigators
Nov 28, 2009·Journal of the American College of Cardiology·Peter LibbyUNKNOWN Leducq Transatlantic Network on Atherothrombosis
Mar 20, 2010·Journal of the American College of Cardiology·Jeffrey S BergerRoger S Blumenthal
Jun 12, 2010·Heart·Dragana Radovanovic, Paul Erne
Jul 28, 2010·Circulation·Ezra A AmsterdamUNKNOWN American Heart Association Exercise, Cardiac Rehabilitation, and Prevention Committee of the Council on Clinical Cardiology,
Dec 24, 2010·European Heart Journal·Catherine McGorrianUNKNOWN INTERHEART Investigators

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