Characteristics and outcomes of atrial fibrillation patients with or without specific symptoms: results from the PREFER in AF registry

European Heart Journal. Quality of Care & Clinical Outcomes
Ameet BakhaiPaulus Kirchhof

Abstract

Atrial fibrillation (AF) is a common condition that is a major cause of stroke. A significant proportion of patients with AF are not classically symptomatic at diagnosis or soon after diagnosis. There is little information comparing their characteristics, treatment, and outcomes of patients with symptoms, which predominate in clinical trials to those without. We analysed data from the Prevention of Thromboembolic Events-European Registry in Atrial Fibrillation. This was a prospective, real-world registry with a 12-month follow-up that included AF patients aged 18 years and over. Patients were divided into those with and without AF symptoms using the European Heart Rhythm Association (EHRA) score (Category I vs. Categories II-IV). Of the 6196 patients (mean age 72 years) with EHRA scores available, 501 (8.1%) were asymptomatic. A lower proportion of asymptomatic patients was female (22.8 vs. 41.2%), with less noted to have heart failure and coronary artery disease (P < 0.01 for all). There were no differences in terms of the prevalence of diabetes, obesity, or prior stroke. Asymptomatic patients had a lower CHA2DS2-VASc score (2.9 ± 1.7 vs. 3.4 ± 1.8; P < 0.01) and HAS-BLED score (1.8 ± 1.1 vs. 2.1 ± 1.2; P < 0.01). During the 1...Continue Reading

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Citations

Apr 1, 2019·European Heart Journal·Stefano MasiStefano Taddei
Jul 28, 2018·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·A John CammAlexander G G Turpie
Apr 3, 2020·Heart·Philipp KrisaiUNKNOWN Swiss-AF study investigators
Feb 20, 2021·The American Journal of Medicine·Harry GibbsUNKNOWN GARFIELD-AF Investigators
Sep 3, 2020·Journal of Psychosomatic Research·Malte KranertAnna Hohneck
May 20, 2021·Indian Pacing and Electrophysiology Journal·Daljeet Kaur SagguCalambur Narasimhan
Jul 21, 2021·Journal of General Internal Medicine·Jayson R BamanRod S Passman
May 17, 2021·Journal of Cardiovascular Electrophysiology·Jayson R BamanJane E Wilcox
Nov 11, 2021·Journal of the American Heart Association·Arjola BanoUNKNOWN of the Swiss‐Investigators

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