Characteristics and Outcomes of Patients with Anti-Glomerular Basement Membrane Antibody Disease and Anti-Neutrophil Cytoplasmic Antibodies

Current Rheumatology Reviews
Percy G BalderiaJonathan A Jefferson

Abstract

It is unclear whether patients with Anti-Glomerular Basement Membrane (GBM) disease and Anti-Neutrophil Cytoplasmic Antibodies (ANCA), so called "Double-Positive" (DP), have a different clinical presentation and outcome compared to patients with anti-GBM antibody disease alone. This study describes the clinical and histologic characteristics as well as the patient and renal outcomes of DP patients at the University of Washington compared to patients with anti-GBM antibody disease alone. Adults admitted to the University of Washington and Harborview Medical Centers from 2000 to 2016 who had a kidney biopsy showing anti-GBM disease characterized by crescentic glomerulonephritis with strong linear staining of glomerular basement membranes for IgG by immunofluorescence were included. Subjects were classified into anti-GBM or DP based on serologic testing. Information on demographics, clinical presentation, biopsy findings, initial treatment, and rates of relapse and patient and renal survival were collected. Continuous and categorical variables were analyzed using the Mann-Whitney U and Fisher's exact tests, respectively. There were 6 anti-GBM and 7 DP patients. Two patients were lost to follow-up after one year. There was no signi...Continue Reading

References

Oct 2, 2004·Kidney International·Jeremy B LevyCharles D Pusey
Aug 23, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Abraham RutgersJan Willem Cohen Tervaert
Aug 27, 2011·Journal of the American Society of Nephrology : JASN·Stephen W OlsonChristina M Yuan
Jan 23, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Bassam AlchiKen Farrington

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