Characteristics and outcomes of sentinel node-positive breast cancer patients after total mastectomy without axillary-specific treatment

Annals of Surgical Oncology
Sarah MilgromAlice Ho

Abstract

Regional failure rates are low in patients with a positive sentinel lymph node biopsy (SLNB) who undergo breast-conserving therapy without axillary lymph node dissection (ALND). The applicability of these findings to total mastectomy (TM) patients is not established. Our aims were to evaluate the characteristics and outcomes of SLNB-positive TM patients who did not receive axillary-specific treatment and to compare them to similar patients who underwent breast-conserving surgery (BCS). A total of 535 patients with early-stage breast cancer who underwent definitive breast surgery (210 TM, 325 BCS), had a positive SLNB and did not receive ALND between 1997 and 2009 were identified from an institutional database. Characteristics and outcomes were compared between the TM and BCS groups. Most patients had stage I to IIA, estrogen receptor-positive, progesterone receptor-positive, Her2-negative invasive ductal carcinoma, with minimal nodal disease. Compared to the BCS group, TM patients were younger, had larger tumors, had higher nomogram scores predicting additional axillary disease and were more likely to receive chemotherapy. Ninety-four percent of the BCS cohort and 5 % of the TM cohort received adjuvant radiotherapy. At a median...Continue Reading

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Citations

Aug 1, 2012·Annals of Surgical Oncology·Sheldon M Feldman, C Alden Sweatman
Oct 1, 2013·The Breast : Official Journal of the European Society of Mastology·Birgitte Vrou OffersenJens Overgaard
Mar 25, 2014·Journal of the American College of Surgeons·Michael S CowherJoseph P Crowe
Sep 24, 2015·The Breast Journal·Raquel F D van la ParraKoop Bosscha
Sep 3, 2014·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·I MeattiniL Livi
Sep 10, 2013·The Breast : Official Journal of the European Society of Mastology·Tejinder KatariaN Karthikeyan
Oct 4, 2016·Annals of Surgical Oncology·Hiram S Cody
Oct 17, 2018·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Ji Hyeon JooBeom Seok Ko
May 30, 2013·American Society of Clinical Oncology Educational Book·Alice Y Ho, Hiram S Cody
Apr 21, 2016·The Breast Journal·Emma GannanUNKNOWN Melbourne Breast Group
Jan 7, 2021·Journal of the National Comprehensive Cancer Network : JNCCN·James SunM Catherine Lee
Sep 13, 2020·Clinical Breast Cancer·Brittany J MathiasJohn V Kiluk
Dec 18, 2019·Seminars in Nuclear Medicine·Valeria M MoncayoJohn N Aarsvold
Feb 16, 2021·Annals of Surgical Oncology·Marissa L G VaneArmando E Giuliano

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