Characteristics and predictors of gastric cancer after Helicobacter pylori eradication

World Journal of Gastroenterology : WJG
Satoki Shichijo, Yoshihiro Hirata

Abstract

Helicobacter pylori (H. pylori) eradication can reduce gastric cancer. However, gastric cancer still develops after eradication, and cases who received eradication therapy are increasing. In this study, we have reviewed the characteristics and predictors of primary gastric cancer developing after H. pylori eradication. In terms of the characteristics, endoscopic, histologic, and molecular characteristics are reported. Endoscopically, gastric cancer after eradication is often depressed-type and shows a gastritis-like appearance, which sometimes makes the diagnosis difficult. Histologically, most gastric cancer after eradication is intestinal type, and non-neoplastic epithelium, also called epithelium with low-grade atypia, is frequently seen over the tumor, which is presumably the cause of the endoscopic gastritis-like appearance. As for molecular characteristics, some markers, such as Ki67, MUC2, and Wnt5a expression, are lower in cancer from patients in whom H. pylori has been eradicated. In terms of predictors, several Japanese studies have reported that severe endoscopic atrophy at eradication is a risk factor for gastric cancer development. Histologic intestinal metaplasia, especially in the corpus, and long-term use of pro...Continue Reading

References

Nov 1, 1976·Journal of the National Cancer Institute·P CorreaW Haenszel
Oct 17, 1991·The New England Journal of Medicine·J ParsonnetR K Sibley
Oct 17, 1991·The New England Journal of Medicine·A NomuraM J Blaser
Jun 17, 1995·Lancet·E J KuipersS G Meuwissen
Sep 15, 2001·The New England Journal of Medicine·N UemuraR J Schlemper
Jan 15, 2004·JAMA : the Journal of the American Medical Association·Benjamin Chun-Yu WongUNKNOWN China Gastric Cancer Study Group
Oct 21, 2004·The Cochrane Database of Systematic Reviews·A FordP Moayyedi
Jan 31, 2006·American Journal of Epidemiology·Yoshinori OishiMitsuo Iida
Feb 28, 2007·The American Journal of Gastroenterology·Ping-I HsuHui-Chun Chen
May 25, 2007·The American Journal of Gastroenterology·Changcheng WangRichard H Hunt
Aug 8, 2007·Gastroenterology·Pelayo Correa, Jeanmarie Houghton
Jun 6, 2009·The American Journal of Gastroenterology·A C de VriesE A J Rauws
Jul 18, 2009·International Journal of Cancer. Journal International Du Cancer·Kimihiko YanaokaMasao Ichinose
Sep 15, 2009·World Journal of Gastroenterology : WJG·Katsuhiro MabeSumio Kawata
Nov 26, 2010·Journal of Gastroenterology and Hepatology·Noboru HanaokaMasaharu Tatsuta
Nov 26, 2010·Journal of Gastroenterology·Susumu TakeKazuhide Yamamoto
May 18, 2011·Journal of Gastroenterology and Hepatology·Kosuke SakitaniKazuhiko Koike
Dec 8, 2011·World Journal of Gastroenterology : WJG·Massimo RuggeDavid Y Graham
Jun 6, 2012·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Noriya UedoKenichi Goda
Oct 5, 2012·Journal of Gastroenterology and Hepatology·Masahira HanedaMasahiko Asaka
Jul 23, 2013·Digestive Surgery·Heike I Grabsch, Patrick Tan
Oct 2, 2013·Scandinavian Journal of Gastroenterology·Masaaki KodamaToshio Fujioka
Aug 5, 2014·Journal of Gastroenterology and Hepatology·Sungmo JungSang Kil Lee
Sep 11, 2014·World Journal of Gastroenterology : WJG·Akiko ShiotaniDavid Y Graham
Mar 18, 2015·Journal of Gastroenterology and Hepatology·Satoki ShichijoKazuhiko Koike
Sep 1, 2015·Gastroenterology Clinics of North America·Masahiro AsakaMomoko Tsuda
Oct 1, 2015·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Genki MoriIchiro Oda
Oct 2, 2015·Digestive Diseases and Sciences·Kazutoshi HoriHiroto Miwa
Oct 13, 2015·World Journal of Gastroenterology : WJG·Masaaki KobayashiShuji Terai
Oct 22, 2015·BMC Gastroenterology·Kosuke SakitaniKazuhiko Koike
Dec 2, 2015·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Kosaku MoribataMasao Ichinose

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Citations

Nov 21, 2018·Frontiers in Immunology·Federica PulvirentiIsabella Quinti
Nov 6, 2018·World Journal of Gastroenterology : WJG·Li-Ping LiuYu-Min Li
Oct 31, 2019·World Journal of Gastrointestinal Oncology·Patrizia BonelliFranco Maria Buonaguro
Mar 28, 2020·United European Gastroenterology Journal
Aug 23, 2019·World Journal of Gastroenterology : WJG·Anca NegovanClaudia Bănescu
Jul 13, 2021·International Journal of Immunopathology and Pharmacology·Wenwen GaoLu Wang
Nov 13, 2021·Journal of Gastrointestinal Cancer·Fatima BoubrikNadia El Kadmiri

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Methods Mentioned

BETA
surgical resection
dissection
biopsy

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