Characteristics and Treatment of Advanced Breast Implant-Associated Anaplastic Large Cell Lymphoma

Plastic and Reconstructive Surgery
Meredith S CollinsMark W Clemens

Abstract

Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) most commonly follows an indolent course; however, a subset of patients display more advanced disease marked by recurrent and disseminated growth refractory to treatment. This study evaluated outcomes of advanced disease, specifically bilateral disease, lymph node involvement, organ metastasis, and/or disease-related death. Published cases of BIA-ALCL from 1997 to 2018 and unpublished cases at the authors' institution were retrospectively reviewed, and patients with advanced disease were selected. Treatment and outcomes were compared against a control of BIA-ALCL subjects without advanced disease. Thirty-nine patients with advanced BIA-ALCL were identified who had bilateral disease (n = 7), lymph node and organ metastasis (stage IIB-IV, n = 24), and disease-related death (n = 8). Sixty-five patients were included in a comparison control group (stage 1A-1C). Treatment types for advanced disease patients were complete surgery, n = 16 (55.2%); limited surgery, n = 19 (65.5%); chemotherapy, n = 26 (89.7%); salvage chemotherapy, n = 11 (37.9%); radiation, n = 15 (51.7%); and autologous stem cell transplant, n = 6 (20.7%). The rates of complete remission for the bila...Continue Reading

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Citations

Jan 3, 2020·Aesthetic Surgery Journal·Trina GhoshTerence M Myckatyn
Dec 18, 2019·Aesthetic Plastic Surgery·Guillermo Ramos-GallardoEnrique Javier Cedillo-Alemán
Jun 27, 2020·Plastic and Reconstructive Surgery·Erica LeeJustin M Sacks
Jul 28, 2019·Diagnostic Cytopathology·Nicoletta D'AlessandrisValeria Ascoli
Sep 23, 2020·Aesthetic Plastic Surgery·Antonio Carlos Pinto OliveiraMarcus Vinicius Martins Collares
Jan 21, 2020·Cancer Treatment Reviews·Antonio MarraGiuseppe Curigliano
Mar 30, 2021·Plastic and Reconstructive Surgery·Neil TannaAdam D Perry
Apr 24, 2021·Plastic and Reconstructive Surgery·M Bradley Calobrace
Apr 24, 2021·Plastic and Reconstructive Surgery·Malke AsaadMark W Clemens
Jun 23, 2021·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Mark G EvansRoberto N Miranda
May 29, 2021·Aesthetic Surgery Journal·Roberto N Miranda, Mario L Marques-Piubelli
Aug 15, 2021·Advances in Surgery·Melissa Camp
Oct 9, 2021·Diagnostic Cytopathology·Sedef EverestAbel Gonzalez

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