Characteristics and treatment of new-onset arthritis after checkpoint inhibitor therapy

RMD Open
Jan LeipeAlla Skapenko

Abstract

Immune checkpoint inhibitors (ICIs) may cause immune-related adverse events (IRAEs). Characterisation and data on treatment of musculoskeletal IRAEs are scarce. In this cohort study, patients receiving ICI therapy who experienced arthralgia were evaluated for the presence of synovitis. Data on demographics, ICI regime, time of onset, imaging and response to therapy of synovitis were prospectively collected. Arthritis was demonstrated in 14 of 16 patients of whom 7 showed monarthritis, 5 had oligoarthritis and 2 had polyarthritis. Patients with ICI-induced arthritis were predominantly male (57%) and seronegative (69%). Regarding the detection of synovitis in staging imaging, moderate sensitivity for contrast-enhanced CT with PET-CT as reference was observed. Disease burden at baseline was high and was significantly reduced after anti-inflammatory treatment. Nine patients were treated with systemic and eight patients with intra-articular glucocorticoids. Six patients who flared on glucocorticoid treatment on tapering were given methotrexate resulting in long-term remission. Patients with synovitis were more likely to have good tumour response. Patients with ICI-induced arthritis were predominantly male and seronegative showing di...Continue Reading

References

Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A EisenhauerJ Verweij
Mar 23, 2012·Nature Reviews. Cancer·Drew M Pardoll
Nov 22, 2014·Journal of Immunotherapy·Matthew M K ChanNicholas Manolios
Jun 17, 2016·Annals of the Rheumatic Diseases·Laura C CappelliClifton O Bingham
Oct 19, 2016·RMD Open·Laura C CappelliClifton O Bingham
Nov 29, 2016·Rheumatic Diseases Clinics of North America·Laura C CappelliClifton O Bingham
Jan 10, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffrey S WeberCaroline Robert
Jan 14, 2017·Arthritis & Rheumatology·Maria E Suarez-AlmazorAdi Diab
Feb 10, 2017·Rheumatology·Nehal NarayanPeter C Taylor
Jun 11, 2017·Annals of the Rheumatic Diseases·Rakiba BelkhirXavier Mariette
Aug 24, 2017·Annals of the Rheumatic Diseases·Sang Taek KimAdi Diab
Oct 12, 2017·Cancer Immunology, Immunotherapy : CII·Kristina Buder-BakhayaJessica C Hassel
Nov 11, 2017·Arthritis Care & Research·Melanie H Smith, Anne R Bass
Dec 2, 2017·Seminars in Arthritis and Rheumatism·Wilson F KuswantoBonnie L Bermas
Mar 27, 2018·Seminars in Arthritis and Rheumatism·Laura C CappelliAmi A Shah

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Citations

Jan 14, 2020·Immunological Reviews·Laura C CappelliErika Darrah
Mar 14, 2020·Current Opinion in Rheumatology·Susanna Jeurling, Laura C Cappelli
Aug 20, 2019·ESMO Open·Karolina BenesovaKarin Jordan
Mar 15, 2019·Current Opinion in Rheumatology·Xerxes PundoleMaria E Suarez-Almazor
Aug 4, 2020·Rheumatology International·Foteini AngelopoulouDimitrios Daoussis
Dec 10, 2019·Rheumatology·Jan Leipe, Xavier Mariette
Nov 30, 2019·Case Reports in Rheumatology·Bicky ThapaCassandra Calabrese
Dec 10, 2019·Rheumatology·Noha Abdel-Wahab, Maria E Suarez-Almazor
Jul 28, 2020·Asia-Pacific Journal of Clinical Oncology·Hui ZhongXiaofeng Zeng
Jul 10, 2019·The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutica·Sofia VazTim Van den Wyngaert
Aug 11, 2020·Expert Review of Clinical Immunology·Sandra G WilliamsSarthak Gupta
May 1, 2020·Der Nephrologe·G S BraunJ Leipe
Feb 17, 2021·The Medical Clinics of North America·Nilasha Ghosh, Anne R Bass
Oct 17, 2020·Cancer Management and Research·Quentin DurrechouAmaury Daste
Apr 28, 2021·Bulletin du cancer·Thomas TingryCyrille B Confavreux
Aug 12, 2021·Oral Diseases·Jack A HarrisGlenn J Hanna

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Methods Mentioned

BETA
biopsy

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Prism

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